Immune activation in HIV infection: what can the natural hosts of simian immunodeficiency virus teach us? - Archive ouverte HAL Access content directly
Journal Articles Current Opinion in HIV and AIDS Year : 2016

Immune activation in HIV infection: what can the natural hosts of simian immunodeficiency virus teach us?

(1) , (2) , (1)
1
2

Abstract

The review summarizes studies in natural hosts, with a particular focus on the control of immune activation and new insights into viral reservoirs. We discuss why these findings are relevant for HIV research today. AIDS resistance in natural hosts is characterized by a rapid control of inflammatory processes in response to simian immunodeficiency virus infection despite persistent viremia. Although CD4 T cells are dramatically depleted in the intestine in primary infection, interleukin 17-producing T helper cells (Th17) are preserved and natural hosts lack microbial translocation. Thus, viral replication in the gut is not sufficient to explain mucosal damage, but additional factors are necessary. Natural hosts also display a lower infection rate of stem-cell memory, central memory and follicular helper T cells. The follicles are characterized by a lack of viral trapping and the viral replication in secondary lymphoid organs is rapidly controlled. Hence, the healthy status of natural hosts is associated with preserved lymphoid environments. Understanding the underlying mechanisms of preservation of Th17 and of the low contribution of stem-cell memory, central memory and follicular helper T cells to viral reservoirs could benefit the search for preventive and curative approaches of HIV. Altogether, the complementarity of the model helps to identify strategies aiming at restoring full capacity of the immune system and decreasing the size of the viral reservoirs.
Fichier principal
Vignette du fichier
Ploquin_COpHiv_06112015.pdf (442.05 Ko) Télécharger le fichier
Origin : Files produced by the author(s)
Loading...

Dates and versions

pasteur-01289403 , version 1 (16-03-2016)

Licence

Copyright

Identifiers

Cite

Mickaël J Ploquin, Guido Silvestri, Michaela Müller-Trutwin. Immune activation in HIV infection: what can the natural hosts of simian immunodeficiency virus teach us?. Current Opinion in HIV and AIDS, 2016, 11 (2), pp.201-8. ⟨10.1097/COH.0000000000000238⟩. ⟨pasteur-01289403⟩

Collections

PASTEUR
284 View
391 Download

Altmetric

Share

Gmail Facebook Twitter LinkedIn More