Skip to Main content Skip to Navigation
Journal articles

The epigenomic landscape of African rainforest hunter-gatherers and farmers

Abstract : The genetic history of African populations is increasingly well documented, yet their patterns of epigenomic variation remain uncharacterized. Moreover, the relative impacts of DNA sequence variation and temporal changes in lifestyle and habitat on the human epigenome remain unknown. Here we generate genome-wide genotype and DNA methylation profiles for 362 rainforest hunter-gatherers and sedentary farmers. We find that the current habitat and historical lifestyle of a population have similarly critical impacts on the methylome, but the biological functions affected strongly differ. Specifically, methylation variation associated with recent changes in habitat mostly concerns immune and cellular functions, whereas that associated with historical lifestyle affects developmental processes. Furthermore, methylation variation—particularly that correlated with historical lifestyle—shows strong associations with nearby genetic variants that, moreover, are enriched in signals of natural selection. Our work provides new insight into the genetic and environmental factors affecting the epigenomic landscape of human populations over time.
Document type :
Journal articles
Complete list of metadatas

Cited literature [71 references]  Display  Hide  Download

https://hal-pasteur.archives-ouvertes.fr/pasteur-01238387
Contributor : Anne Lassailly-Bondaz <>
Submitted on : Friday, December 4, 2015 - 5:45:09 PM
Last modification on : Wednesday, October 7, 2020 - 3:36:13 PM
Long-term archiving on: : Saturday, April 29, 2017 - 5:51:39 AM

File

ncomms10047.pdf
Publication funded by an institution

Licence


Distributed under a Creative Commons Attribution 4.0 International License

Identifiers

Citation

Maud Fagny, Etienne Patin, Maxime Rotival, Julia L. Macisaac, Timothée Flutre, et al.. The epigenomic landscape of African rainforest hunter-gatherers and farmers. Nature Communications, Nature Publishing Group, 2015, 6, 11 p. ⟨10.1038/ncomms10047⟩. ⟨pasteur-01238387⟩

Share

Metrics

Record views

1058

Files downloads

1560