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Journal articles
NFIL3 Orchestrates the Emergence of Common Helper Innate Lymphoid Cell Precursors
Abstract : Innate lymphoid cells (ILCs) are a family of effectors that originate from a common innate lymphoid cell progenitor. However, the transcriptional program that sets the identity of the ILC lineage remains elusive. Here, we show that NFIL3 is a critical regulator of the common helper-like innate lymphoid cell progenitor (CHILP). Cell-intrinsic Nfil3 ablation led to variably impaired development of fetal and adult ILC subsets. Conditional gene targeting demonstrated that NFIL3 exerted its function prior to ILC subset commitment. Accordingly, NFIL3 ablation resulted in loss of ID2+ CHILP and PLZF+ ILC progenitors. Nfil3 expression in lymphoid progenitors was under the control of the mesenchyme-derived hematopoietin IL-7, and NFIL3 exerted its function via direct Id2 regulation in the CHILP. Moreover, ectopic Id2 expression in Nfil3-null precursors rescued defective ILC lineage development in vivo. Our data establish NFIL3 as a key regulator of common helper- like ILC progenitors as they emerge during early lymphopoiesis.
Cited literature [47 references]
https://hal-pasteur.archives-ouvertes.fr/pasteur-01138721
Contributor : James Di Santo <>
Submitted on : Thursday, April 2, 2015 - 3:11:24 PM
Last modification on : Tuesday, December 15, 2020 - 6:50:02 PM
Long-term archiving on: : Tuesday, April 18, 2017 - 9:14:16 AM
Contributor : James Di Santo <>
Submitted on : Thursday, April 2, 2015 - 3:11:24 PM
Last modification on : Tuesday, December 15, 2020 - 6:50:02 PM
Long-term archiving on: : Tuesday, April 18, 2017 - 9:14:16 AM
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Xu_Cell Reports_2015.pdf
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