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Global phylogeny of Shigella sonnei strains from limited single nucleotide polymorphisms (SNPs) and development of a rapid and cost-effective SNP-typing scheme for strain identification by high-resolution melting analysis

Abstract : The current Shigella sonnei pandemic involves geographically associated, multidrug-resistant clones. This study has demonstrated that S. sonnei phylogeny can be accurately defined with limited single nucleotide polymorphisms (SNPs). By typing 6 informative SNPs using a high-resolution melting (HRM) assay, major S. sonnei lineages/sublineages can be identified as defined by whole-genome variation.
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Submitted on : Thursday, February 12, 2015 - 10:10:14 AM
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Vartul Sangal, Kathryn E. Holt, Jianfeng Yuan, Derek J Brown, Ingrid Filliol-Toutain, et al.. Global phylogeny of Shigella sonnei strains from limited single nucleotide polymorphisms (SNPs) and development of a rapid and cost-effective SNP-typing scheme for strain identification by high-resolution melting analysis. Journal of Clinical Microbiology, American Society for Microbiology, 2013, 51 (1), pp.303-305. ⟨10.1128/JCM.02238-12⟩. ⟨pasteur-01115898⟩

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