Global phylogeny of Shigella sonnei strains from limited single nucleotide polymorphisms (SNPs) and development of a rapid and cost-effective SNP-typing scheme for strain identification by high-resolution melting analysis - Archive ouverte HAL Access content directly
Journal Articles Journal of Clinical Microbiology Year : 2013

Global phylogeny of Shigella sonnei strains from limited single nucleotide polymorphisms (SNPs) and development of a rapid and cost-effective SNP-typing scheme for strain identification by high-resolution melting analysis

Abstract

The current Shigella sonnei pandemic involves geographically associated, multidrug-resistant clones. This study has demonstrated that S. sonnei phylogeny can be accurately defined with limited single nucleotide polymorphisms (SNPs). By typing 6 informative SNPs using a high-resolution melting (HRM) assay, major S. sonnei lineages/sublineages can be identified as defined by whole-genome variation.

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pasteur-01115898 , version 1 (12-02-2015)

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Vartul Sangal, Kathryn E. Holt, Jianfeng Yuan, Derek J Brown, Ingrid Filliol-Toutain, et al.. Global phylogeny of Shigella sonnei strains from limited single nucleotide polymorphisms (SNPs) and development of a rapid and cost-effective SNP-typing scheme for strain identification by high-resolution melting analysis. Journal of Clinical Microbiology, 2013, 51 (1), pp.303-305. ⟨10.1128/JCM.02238-12⟩. ⟨pasteur-01115898⟩

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