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Journal articles
Chimeric NP Non Coding Regions between Type A and C Influenza Viruses Reveal Their Role in Translation Regulation
Abstract : Exchange of the non coding regions of the NP segment between type A and C influenza viruses was used to demonstrate the importance not only of the proximal panhandle, but also of the initial distal panhandle strength in type specificity. Both elements were found to be compulsory to rescue infectious virus by reverse genetics systems. Interestingly, in type A influenza virus infectious context, the length of the NP segment 5' NC region once transcribed into mRNA was found to impact its translation, and the level of produced NP protein consequently affected the level of viral genome replication.
Cited literature [51 references]
https://hal-pasteur.archives-ouvertes.fr/pasteur-01103991
Contributor : Cyril Barbezange <>
Submitted on : Thursday, January 15, 2015 - 5:51:00 PM
Last modification on : Sunday, May 31, 2020 - 10:16:03 AM
Long-term archiving on: : Friday, September 11, 2015 - 6:53:02 AM
Contributor : Cyril Barbezange <>
Submitted on : Thursday, January 15, 2015 - 5:51:00 PM
Last modification on : Sunday, May 31, 2020 - 10:16:03 AM
Long-term archiving on: : Friday, September 11, 2015 - 6:53:02 AM
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2014_PlosOne_Crescenzo_NP.pdf
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