Abstract : Maraviroc is a non-peptidic, low molecular weight CC chemokine receptor 5 (CCR5) ligand that has recently been marketed for the treatment of HIV infected individuals. This review discusses recent molecular modeling studies of CCR5 by homology to CXC che- mokine receptor 4, their contribution to the under- standing of the allosteric mode of action of the inhibitor and their potential for the development of future drugs with improved efficiency and preservation of CCR5 biological functions.
https://hal-pasteur.archives-ouvertes.fr/pasteur-00743086 Contributor : Cécile PhamConnect in order to contact the contributor Submitted on : Friday, October 18, 2013 - 7:00:05 AM Last modification on : Thursday, April 7, 2022 - 10:10:30 AM Long-term archiving on: : Friday, March 31, 2017 - 2:38:17 PM
Bernard Lagane, Javier Garcia-Perez, Esther Kellenberger. Modeling the allosteric modulation of CCR5 function by Maraviroc. Drug Discovery Today: Technologies, Elsevier, 2012, 10 (2), pp.e297-e305. ⟨10.1016/j.ddtec.2012.07.011⟩. ⟨pasteur-00743086⟩