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Journal Articles Drug Discovery Today: Technologies Year : 2012

Modeling the allosteric modulation of CCR5 function by Maraviroc

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Bernard Lagane
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Abstract

Maraviroc is a non-peptidic, low molecular weight CC chemokine receptor 5 (CCR5) ligand that has recently been marketed for the treatment of HIV infected individuals. This review discusses recent molecular modeling studies of CCR5 by homology to CXC che- mokine receptor 4, their contribution to the under- standing of the allosteric mode of action of the inhibitor and their potential for the development of future drugs with improved efficiency and preservation of CCR5 biological functions.
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Dates and versions

pasteur-00743086 , version 1 (18-10-2013)

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Bernard Lagane, Javier Garcia-Perez, Esther Kellenberger. Modeling the allosteric modulation of CCR5 function by Maraviroc. Drug Discovery Today: Technologies, 2012, 10 (2), pp.e297-e305. ⟨10.1016/j.ddtec.2012.07.011⟩. ⟨pasteur-00743086⟩
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