Modeling the allosteric modulation of CCR5 function by Maraviroc

Bernard Lagane (1) , Javier Garcia-Perez (2) , Esther Kellenberger (3)

1 Pathogénie Virale
2 Insituto de Salud Carlos III
3 UNISTRA - Université de Strasbourg

Maraviroc is a non-peptidic, low molecular weight CC chemokine receptor 5 (CCR5) ligand that has recently been marketed for the treatment of HIV infected individuals. This review discusses recent molecular modeling studies of CCR5 by homology to CXC che- mokine receptor 4, their contribution to the under- standing of the allosteric mode of action of the inhibitor and their potential for the development of future drugs with improved efficiency and preservation of CCR5 biological functions.

Domains: Life Sciences [q-bio]; Microbiology and Parasitology

Bernard Lagane, Javier Garcia-Perez, Esther Kellenberger. Modeling the allosteric modulation of CCR5 function by Maraviroc. Drug Discovery Today: Technologies, 2012, 10 (2), pp.e297-e305. ⟨10.1016/j.ddtec.2012.07.011⟩. ⟨pasteur-00743086⟩