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Modeling the allosteric modulation of CCR5 function by Maraviroc

Abstract : Maraviroc is a non-peptidic, low molecular weight CC chemokine receptor 5 (CCR5) ligand that has recently been marketed for the treatment of HIV infected individuals. This review discusses recent molecular modeling studies of CCR5 by homology to CXC che- mokine receptor 4, their contribution to the under- standing of the allosteric mode of action of the inhibitor and their potential for the development of future drugs with improved efficiency and preservation of CCR5 biological functions.
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Submitted on : Friday, October 18, 2013 - 7:00:05 AM
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Bernard Lagane, Javier Garcia-Perez, Esther Kellenberger. Modeling the allosteric modulation of CCR5 function by Maraviroc. Drug Discovery Today: Technologies, Elsevier, 2012, 10 (2), pp.e297-e305. ⟨10.1016/j.ddtec.2012.07.011⟩. ⟨pasteur-00743086⟩

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