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Journal articles
Plasmodium falciparum drug resistance in Madagascar: facing the spread of unusual pfdhfr and pfmdr-1 haplotypes and the decrease of dihydroartemisinin susceptibility.
Valérie Andriantsoanirina
1
Arsène Ratsimbasoa
2
Christiane Bouchier
3
Martial Jahevitra
1
Stéphane Rabearimanana
1
Rogelin Radrianjafy
1
Voahangy Andrianaranjaka
1
Tantely Randriantsoa
1
Marie Ange Rason
1
Magali Tichit
3
Léon Paul Rabarijaona
4
Odile Mercereau-Puijalon
5
Rémy Durand
6
Didier Ménard
1, 5, *
Valérie Andriantsoanirina 1
Author
Arsène Ratsimbasoa 2
Author
Christiane Bouchier 3
Author
Martial Jahevitra 1
Author
Stéphane Rabearimanana 1
Author
Rogelin Radrianjafy 1
Author
Voahangy Andrianaranjaka 1
Author
Tantely Randriantsoa 1
Author
Marie Ange Rason 1
Author
Magali Tichit 3
Author
Léon Paul Rabarijaona 4
Author
Odile Mercereau-Puijalon 5
Author
Rémy Durand 6
Author
Didier Ménard 1, 5
Correspondent author IdHAL : didier-menard ORCID : https://orcid.org/0000-0003-1357-4495
1
Institut Pasteur de Madagascar (B.P. 1274 Antananarivo - Madagascar)
- RIIP - Réseau International des Instituts Pasteur (25, rue du Dr Roux 75724 Paris Cedex 15 - France)
2
Departement de Santé Publique (Madagascar)
- Université d'Antananarivo (BP 566 - Antananarivo 101 - Madagascar - Madagascar)
- Faculté de Médecine (France)
3
Génopole (25-28 rue du Docteur Roux, F-75724 Paris Cedex 15 - France)
- Institut Pasteur [Paris] (25-28, rue du docteur Roux, 75724 Paris cedex 15 - France)
5
Immunologie moléculaire des parasites (25-28 rue du Docteur Roux F-75724 Paris Cedex 15 - France)
- Institut Pasteur [Paris] (25-28, rue du docteur Roux, 75724 Paris cedex 15 - France)
- CNRS - Centre National de la Recherche Scientifique : UMR2581 (France)
6
Laboratoire de Parasitologie-Mycologie (Hôpital Avicenne, 125 rue de Stalingrad, 93009, Bobigny Cedex - France)
Abstract : The aim of this study was to provide the first comprehensive spatiotemporal picture of Plasmodium falciparum resistance in various geographic areas in Madagascar. Additional data about the antimalarial resistance in the neighboring islands of the Comoros archipelago were also collected. We assessed the prevalence of pfcrt, pfmdr-1, pfdhfr, and pfdhps mutations and the pfmdr-1 gene copy number in 1,596 P. falciparum isolates collected in 26 health centers (20 in Madagascar and 6 in the Comoros Islands) from 2006 to 2008. The in vitro responses to a panel of drugs by 373 of the parasite isolates were determined. The results showed (i) unusual profiles of chloroquine susceptibility in Madagascar, (ii) a rapid rise in the frequency of parasites with both the pfdhfr and the pfdhps mutations, (iii) the alarming emergence of the single pfdhfr 164L genotype, and (iv) the progressive loss of the most susceptible isolates to artemisinin derivatives. In the context of the implementation of the new national policy for the fight against malaria, continued surveillance for the detection of P. falciparum resistance in the future is required.
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Journal articles
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https://hal-pasteur.archives-ouvertes.fr/pasteur-00741124
Contributor : Didier Menard <>
Submitted on : Thursday, October 11, 2012 - 5:27:54 PM
Last modification on : Tuesday, September 1, 2020 - 3:06:17 AM
Long-term archiving on: : Saturday, December 17, 2016 - 12:27:29 AM
Contributor : Didier Menard <>
Submitted on : Thursday, October 11, 2012 - 5:27:54 PM
Last modification on : Tuesday, September 1, 2020 - 3:06:17 AM
Long-term archiving on: : Saturday, December 17, 2016 - 12:27:29 AM
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Identifiers
- HAL Id : pasteur-00741124, version 1
- DOI : 10.1128/AAC.00610-09
- PUBMED : 19704124
Collections
PASTEUR | CNRS | RIIP | RIIP_MADAGASCAR | AFRIQ
Citation
Valérie Andriantsoanirina, Arsène Ratsimbasoa, Christiane Bouchier, Martial Jahevitra, Stéphane Rabearimanana, et al.. Plasmodium falciparum drug resistance in Madagascar: facing the spread of unusual pfdhfr and pfmdr-1 haplotypes and the decrease of dihydroartemisinin susceptibility.. Antimicrobial Agents and Chemotherapy, American Society for Microbiology, 2009, 53 (11), pp.4588-97. ⟨10.1128/AAC.00610-09⟩. ⟨pasteur-00741124⟩
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