Pathogenesis of flavivirus infections: using and abusing the host cell. - Institut Pasteur Access content directly
Journal Articles Cell Host and Microbe Year : 2009

Pathogenesis of flavivirus infections: using and abusing the host cell.

Abstract

Flaviviruses, such as the dengue virus and the West Nile virus, are emerging arthropod-borne viruses that represent an immense global health problem. Considerable progress has been made in understanding flavivirus structure and replication strategies, but only now are the complex molecular interactions between the virus and host cell starting to be unraveled. In this Review, we discuss the ongoing efforts toward elucidating the molecular mechanisms that allow flaviviruses to manipulate host cell functions for successful infection. We draw attention to the importance of these studies in defining the pathogenesis of flaviviral diseases.

Dates and versions

pasteur-00429869 , version 1 (04-11-2009)

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Maria-Dolores Fernandez-Garcia, Michela Mazzon, Michael Jacobs, Ali Amara. Pathogenesis of flavivirus infections: using and abusing the host cell.. Cell Host and Microbe, 2009, 5 (4), pp.318-28. ⟨10.1016/j.chom.2009.04.001⟩. ⟨pasteur-00429869⟩

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