Skip to Main content Skip to Navigation
Journal articles

Cellular and behavioral effects of cranial irradiation of the subventricular zone in adult mice.: Effects of SVZ irradiation

Abstract : BACKGROUND: In mammals, new neurons are added to the olfactory bulb (OB) throughout life. Most of these new neurons, granule and periglomerular cells originate from the subventricular zone (SVZ) lining the lateral ventricles and migrate via the rostral migratory stream toward the OB. Thousands of new neurons appear each day, but the function of this ongoing neurogenesis remains unclear. METHODOLOGY/PRINCIPAL FINDINGS: In this study, we irradiated adult mice to impair constitutive OB neurogenesis, and explored the functional impacts of this irradiation on the sense of smell. We found that focal irradiation of the SVZ greatly decreased the rate of production of new OB neurons, leaving other brain areas intact. This effect persisted for up to seven months after exposure to 15 Gray. Despite this robust impairment, the thresholds for detecting pure odorant molecules and short-term olfactory memory were not affected by irradiation. Similarly, the ability to distinguish between odorant molecules and the odorant-guided social behavior of irradiated mice were not affected by the decrease in the number of new neurons. Only long-term olfactory memory was found to be sensitive to SVZ irradiation. CONCLUSION/SIGNIFICANCE: These findings suggest that the continuous production of adult-generated neurons is involved in consolidating or restituting long-lasting olfactory traces.
Document type :
Journal articles
Complete list of metadatas

Cited literature [50 references]  Display  Hide  Download

https://hal-pasteur.archives-ouvertes.fr/pasteur-00419960
Contributor : Françoise Lazarini <>
Submitted on : Friday, September 25, 2009 - 4:53:00 PM
Last modification on : Wednesday, October 14, 2020 - 3:58:31 AM
Long-term archiving on: : Tuesday, June 15, 2010 - 10:15:58 PM

File

Lazarinietal2009.pdf
Publisher files allowed on an open archive

Identifiers

Collections

Citation

Françoise Lazarini, Marc-André Mouthon, Gilles Gheusi, Fabrice de Chaumont, Olivo-Marin Jean-Christophe, et al.. Cellular and behavioral effects of cranial irradiation of the subventricular zone in adult mice.: Effects of SVZ irradiation. PLoS ONE, Public Library of Science, 2009, 4 (9), 2009 Sep 15;4(9):e7017.Click here to read. ⟨10.1371/journal.pone.0007017⟩. ⟨pasteur-00419960⟩

Share

Metrics

Record views

573

Files downloads

1020