Skip to Main content Skip to Navigation
New interface
Journal articles

A large new subset of TRIM genes highly diversified by duplication and positive selection in teleost fish.

Abstract : BACKGROUND: In mammals, the members of the tripartite motif (TRIM) protein family are involved in various cellular processes including innate immunity against viral infection. Viruses exert strong selective pressures on the defense system. Accordingly, antiviral TRIMs have diversified highly through gene expansion, positive selection and alternative splicing. Characterizing immune TRIMs in other vertebrates may enlighten their complex evolution. RESULTS: We describe here a large new subfamily of TRIMs in teleosts, called finTRIMs, identified in rainbow trout as virus-induced transcripts. FinTRIMs are formed of nearly identical RING/B-box regions and C-termini of variable length; the long variants include a B30.2 domain. The zebrafish genome harbors a striking diversity of finTRIMs, with 84 genes distributed in clusters on different chromosomes. A phylogenetic analysis revealed different subsets suggesting lineage-specific diversification events. Accordingly, the number of fintrim genes varies greatly among fish species. Conserved syntenies were observed only for the oldest fintrims. The closest mammalian relatives are trim16 and trim25, but they are not true orthologs. The B30.2 domain of zebrafish finTRIMs evolved under strong positive selection. The positions under positive selection are remarkably congruent in finTRIMs and in mammalian antiviral TRIM5alpha, concentrated within a viral recognition motif in mammals. The B30.2 domains most closely related to finTRIM are found among NOD-like receptors (NLR), indicating that the evolution of TRIMs and NLRs was intertwined by exon shuffling. CONCLUSION: The diversity, evolution, and features of finTRIMs suggest an important role in fish innate immunity; this would make them the first TRIMs involved in immunity identified outside mammals.
Document type :
Journal articles
Complete list of metadata

Cited literature [65 references]  Display  Hide  Download
Contributor : Jean-Pierre Levraud Connect in order to contact the contributor
Submitted on : Tuesday, June 30, 2009 - 4:22:47 PM
Last modification on : Thursday, April 7, 2022 - 10:10:08 AM
Long-term archiving on: : Monday, October 15, 2012 - 2:55:22 PM


Publisher files allowed on an open archive



Lieke M van Der Aa, Jean-Pierre Levraud, Malika Yahmi, Emilie Lauret, Valérie Briolat, et al.. A large new subset of TRIM genes highly diversified by duplication and positive selection in teleost fish.. BMC Biology, 2009, 7 (7), pp.7. ⟨10.1186/1741-7007-7-7⟩. ⟨pasteur-00400402⟩



Record views


Files downloads