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The role of cellular competition in B cell survival and selection of B cell repertoires.

Abstract : We studied the competitive repopulation by different B cells of irradiated mice reconstituted with bone marrow from either congenic or Ig-transgenic (TG) mice mixed at different ratios. We found that after reconstitution, the number of B cells recovered in the different chimeras is similar and independent of the ratio of injected cells. In chimeras hosting TG and non-TG cells, the relative representation of the donor cell lineages diverges from the ratios present in the inoculum, i.e. at the periphery, non-TG cells are preferentially selected. Selection of non-TG cells only occurs when population growth plateaus, i.e. when resources become limiting and competition starts to operate. Selection of non-TG cells depends on surface Ig expression, and they are selected because they have a longer survival. Finally, the life-expectancy of the same B cell population differs depending upon the second population present. The present results show that the life-span and the population size of each B cell clone can be altered (interfered with) by the presence of a second cell population, demonstrating the existence of cellular competition among B cells. Our findings establish the role of cellular competition in the selection of B cell repertoires and the existence of a hierarchy of B cell selection in the absence of antigenic stimulation. The implications of cellular competition on our understanding of the immune system are discussed.
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https://hal-pasteur.archives-ouvertes.fr/pasteur-00329445
Contributor : Marie-Christine Vougny <>
Submitted on : Friday, October 10, 2008 - 4:00:51 PM
Last modification on : Monday, January 13, 2020 - 5:08:14 PM

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Antonio A. Freitas, Maria Manuela Rosado, Anne-Claire Viale, Alf Grandien. The role of cellular competition in B cell survival and selection of B cell repertoires.. European Journal of Immunology, Wiley-VCH Verlag, 1995, 25 (6), pp.1729-38. ⟨10.1002/eji.1830250636⟩. ⟨pasteur-00329445⟩

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