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Impaired regeneration of the peripheral B cell repertoire from bone marrow following lymphopenia in old mice.

Abstract : Aging is associated with a decreased production of B cells by the bone marrow and an increased life-span of peripheral B cells. To determine whether the decreased bone marrow B cell production is linked to the increased life-span of B cells in old mice, B cell regeneration following lymphopenia was studied in young and old mice. The rate of bone marrow pre-B cell and of splenic B cell regeneration is slower in irradiated, old compared to irradiated, young recipients of young, congeneic bone marrow. This finding reflects an age-associated defect in the bone marrow microenvironment. As the bone marrow is the only source of a diverse population of B cells, we measured the diversity of the splenic B cell repertoire regenerated following drug-induced lymphopenia in old and young mice. The heterogeneity of mRNA size from IgH complementarity determining region 3 (CDR3) was more restricted in splenic B cells from old compared to young mice providing additional evidence for an age-associated impairment in B cell production by the bone marrow.
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https://hal-pasteur.archives-ouvertes.fr/pasteur-00327510
Contributor : Marie-Christine Vougny <>
Submitted on : Wednesday, October 8, 2008 - 3:55:58 PM
Last modification on : Monday, January 13, 2020 - 5:08:06 PM

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Fang Li, F. Jin, Antonio Freitas, Paul Szabo, Marc E. Weksler. Impaired regeneration of the peripheral B cell repertoire from bone marrow following lymphopenia in old mice.. European Journal of Immunology, Wiley-VCH Verlag, 2001, 31 (2), pp.500-5. ⟨10.1002/1521-4141(200102)31:2<500::AID-IMMU500>3.0.CO;2-C⟩. ⟨pasteur-00327510⟩

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