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Cyclosporin A therapy differently affects immunological-relevant gene expression following immunization.

Abstract : We have studied the effect of cyclosporin A (CSA) on the expression of genes involved in the immune response in mice bearing a transgenic T cell receptor specific for the peptide 88-104 of the pigeon cytochrome c. Immunization of mice treated with CSA resulted in the blockade of the IL2, IFN-gamma, CXCR-5, CCR-5 and CD25 gene transcription. CSA decreased the density of CD69 on T-cells but did not interfere with the induction of the chemokine receptors CCR-1, CCR-4, CXCR2 and CXCR-4. Finally, CSA accelerated the kinetics of CD44 and CD62L expression or re-expression and increased the density of both markers on T-cell membrane. The present data show that priming in presence of CSA resulted in the acquisition of a particular phenotype by the activated T-cells.
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https://hal-pasteur.archives-ouvertes.fr/pasteur-00327455
Contributor : Marie-Christine Vougny <>
Submitted on : Wednesday, October 8, 2008 - 2:54:58 PM
Last modification on : Monday, January 13, 2020 - 5:08:06 PM

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Laurent Mascarell, Paolo Truffa-Bachi. Cyclosporin A therapy differently affects immunological-relevant gene expression following immunization.. Immunology Letters, Elsevier, 2002, 84 (2), pp.137-43. ⟨10.1016/S0165-2478(02)00157-8⟩. ⟨pasteur-00327455⟩

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