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Journal articles
Early phosphatidylinositol 3-kinase/Akt pathway activation limits poliovirus-induced JNK-mediated cell death.
Abstract : Poliovirus (PV)-induced apoptosis seems to play a major role in tissue injury in the central nervous system (CNS). We have previously shown that this process involves PV-induced Bax-dependent mitochondrial dysfunction mediated by early JNK activation in IMR5 neuroblastoma cells. We showed here that PV simultaneously activates the phosphatidylinositol 3-kinase (PI3K)/Akt survival signaling pathway in these cells, limiting the extent of JNK activation and thereby cell death. JNK inhibition is associated with PI3K-dependent negative regulation of the apoptosis signal-regulating kinase 1, which acts upstream from JNK in PV-infected IMR5 cells. In poliomyelitis, this survival pathway may limit the spread of PV-induced damage in the CNS.
Cited literature [14 references]
https://hal-pasteur.archives-ouvertes.fr/pasteur-00316053
Contributor : Hélène Ribierre <>
Submitted on : Thursday, September 18, 2008 - 3:45:39 PM
Last modification on : Monday, January 13, 2020 - 5:08:09 PM
Long-term archiving on: : Thursday, June 3, 2010 - 7:23:09 PM
Contributor : Hélène Ribierre <>
Submitted on : Thursday, September 18, 2008 - 3:45:39 PM
Last modification on : Monday, January 13, 2020 - 5:08:09 PM
Long-term archiving on: : Thursday, June 3, 2010 - 7:23:09 PM
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Autret_et_al_2008.pdf
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