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Early phosphatidylinositol 3-kinase/Akt pathway activation limits poliovirus-induced JNK-mediated cell death.

Abstract : Poliovirus (PV)-induced apoptosis seems to play a major role in tissue injury in the central nervous system (CNS). We have previously shown that this process involves PV-induced Bax-dependent mitochondrial dysfunction mediated by early JNK activation in IMR5 neuroblastoma cells. We showed here that PV simultaneously activates the phosphatidylinositol 3-kinase (PI3K)/Akt survival signaling pathway in these cells, limiting the extent of JNK activation and thereby cell death. JNK inhibition is associated with PI3K-dependent negative regulation of the apoptosis signal-regulating kinase 1, which acts upstream from JNK in PV-infected IMR5 cells. In poliomyelitis, this survival pathway may limit the spread of PV-induced damage in the CNS.
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Submitted on : Thursday, September 18, 2008 - 3:45:39 PM
Last modification on : Monday, January 13, 2020 - 5:08:09 PM
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Arnaud Autret, Sandra Martin-Latil, Cynthia Brisac, Laurence Mousson, Florence Colbère-Garapin, et al.. Early phosphatidylinositol 3-kinase/Akt pathway activation limits poliovirus-induced JNK-mediated cell death.. Journal of Virology, American Society for Microbiology, 2008, 82 (7), pp.3796-802. ⟨10.1128/JVI.02020-07⟩. ⟨pasteur-00316053⟩

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