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The engagement of activating FcgammaRs inhibits primate lentivirus replication in human macrophages.

Abstract : We previously reported that the stimulation of monocyte-derived macrophages (MDM) by plate-bound i.v. Igs inhibits HIV-1 replication. In this study, we show that IgG immune complexes also suppress HIV-1 replication in MDMs and that activating receptors for the Fc portion of IgG-FcgammaRI, FcgammaRIIA, and FcgammaRIII-are responsible for the inhibition. MDM stimulation through FcgammaRs induces activation signals and the secretion of HIV-1 modulatory cytokines, such as M-CSF, TNF-alpha, and macrophage-derived chemokine. However, none of these cytokines contribute to HIV-1 suppression. HIV-1 entry and postintegration steps of viral replication are not affected, whereas reduced levels of reverse transcription products and of integrated proviruses, as determined by real-time PCR analysis, account for the suppression of HIV-1 gene expression in FcgammaR-activated MDMs. We found that FcgammaR-dependent activation of MDMs also inhibits the replication of HIV-2, SIVmac, and SIVagm, suggesting a common control mechanism for primate immunodeficiency lentiviruses in activated macrophages.
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Contributor : Gianfranco Pancino Connect in order to contact the contributor
Submitted on : Tuesday, August 21, 2007 - 1:12:09 PM
Last modification on : Thursday, April 7, 2022 - 10:10:20 AM
Long-term archiving on: : Friday, April 9, 2010 - 1:01:17 AM


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Annie David, Asier Sáez-Cirión, Pierre Versmisse, Odile Malbec, Bruno Iannascoli, et al.. The engagement of activating FcgammaRs inhibits primate lentivirus replication in human macrophages.. Journal of Immunology, 2006, 177 (9), pp.6291-300. ⟨10.4049/jimmunol.177.9.6291⟩. ⟨pasteur-00167539⟩



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