Skip to Main content Skip to Navigation
Journal articles

Discovery of bicyclic thymidine analogues as selective and high-affinity inhibitors of Mycobacterium tuberculosis thymidine monophosphate kinase.

Abstract : Thymidine monophosphate kinase of Mycobacterium tuberculosis (TMPKmt) represents an attractive target for selectively blocking bacterial DNA synthesis. Hereby, we report on the discovery of a novel class of bicyclic nucleosides (10 and 11) and one dinucleoside (12), belonging to the most selective inhibitors of TMPKmt discovered so far.
Document type :
Journal articles
Complete list of metadatas

https://hal-pasteur.archives-ouvertes.fr/pasteur-00166959
Contributor : Hélène Munier-Lehmann <>
Submitted on : Monday, August 13, 2007 - 4:35:36 PM
Last modification on : Monday, January 13, 2020 - 5:08:05 PM

Links full text

Identifiers

Collections

Citation

Veerle Vanheusden, Hélène Munier-Lehmann, Matheus Froeyen, Roger Busson, Jef Rozenski, et al.. Discovery of bicyclic thymidine analogues as selective and high-affinity inhibitors of Mycobacterium tuberculosis thymidine monophosphate kinase.. Journal of Medicinal Chemistry, American Chemical Society, 2004, 47 (25), pp.6187-94. ⟨10.1021/jm040847w⟩. ⟨pasteur-00166959⟩

Share

Metrics

Record views

127