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Preparation of synthetic glycoconjugates as potential vaccines against Shigella flexneri serotype 2a disease.

Abstract : The synthesis of three neoglycopeptides incorporating carbohydrate haptens, differing in length, covalently linked to a non natural universal T helper peptide is disclosed. They were synthesized according to a blockwise strategy based on the condensation of appropriate di-, tri-, and tetrasaccharide trichloroacetimidate donors onto an azidoethyl 2-acetamido-2-deoxybeta-D-glucopyranoside acceptor. Use of thiol-maleimide coupling chemistry allowed site-selective efficient conjugation.
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https://hal-pasteur.archives-ouvertes.fr/pasteur-00166853
Contributor : Françoise Baleux <>
Submitted on : Friday, August 10, 2007 - 3:04:55 PM
Last modification on : Sunday, June 7, 2020 - 4:38:02 PM

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Karen Wright, Catherine Guerreiro, Isabelle Laurent, Françoise Baleux, Laurence A Mulard. Preparation of synthetic glycoconjugates as potential vaccines against Shigella flexneri serotype 2a disease.. Organic and Biomolecular Chemistry, Royal Society of Chemistry, 2004, 2 (10), pp.1518-27. ⟨10.1039/b400986J⟩. ⟨pasteur-00166853⟩

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