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Journal articles
Synthesis and immunological evaluation of an antitumor neoglycopeptide vaccine bearing a novel homoserine Tn antigen.
Abstract : As part of our program on Tn-specific anti-tumor immunotherapy, our aim was to vary the nature of the aglyconic part of the tumor-associated Tn antigen (alpha-d-GalNAc-Ser/Thr). This report describes the synthesis of Fmoc-hSer-(alpha-d-GalNAc)-OH (4) in 19% overall yield from protected aspartic acid. The building block 4 was incorporated as trimeric clusters into a glycopeptide vaccine [MAG:Tn(hSer)3-PV], using solid-phase peptide synthesis. When injected in mice, the resulting MAG induces a strong antibody response, which recognizes native tumor-associated antigens (TAA) at the surface of human tumor cells. This approach may be extended to the use of other nonnatural TAA in order to improve half-life of synthetic anti-cancer vaccines.
https://hal-pasteur.archives-ouvertes.fr/pasteur-00166850
Contributor : Sylvie Bay <>
Submitted on : Friday, August 10, 2007 - 2:57:16 PM
Last modification on : Wednesday, December 2, 2020 - 9:38:03 AM
Contributor : Sylvie Bay <>
Submitted on : Friday, August 10, 2007 - 2:57:16 PM
Last modification on : Wednesday, December 2, 2020 - 9:38:03 AM