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The antimicrobial peptide dermaseptin S4 inhibits HIV-1 infectivity in vitro.

Abstract : Most of HIV-1 infections are acquired through sexual contact. In the absence of a preventive vaccine, the development of topical microbicides that can block infection at the mucosal tissues is needed. Dermaseptin S4 (DS4) is an antimicrobial peptide derived from amphibian skin, which displays a broad spectrum of activity against bacteria, yeast, filamentous fungi, and herpes simplex virus type 1. We show here that DS4 inhibits cell-free and cell-associated HIV-1 infection of P4-CCR5 indicator cells and human primary T lymphocytes. The peptide is effective against R5 and X4 primary isolates and laboratory-adapted strains of HIV-1. Its activity is directed against HIV-1 particles by disrupting the virion integrity. Increasing the number of DS4-positive charges reduced cytotoxicity without affecting the antiviral activity. The modified DS4 inhibited HIV-1 capture by dendritic cells and subsequent transmission to CD4(+) T cells, as well as HIV-1 binding on HEC-1 endometrial cells and transcytosis through a tight epithelial monolayer.
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Contributor : Françoise Baleux Connect in order to contact the contributor
Submitted on : Thursday, August 9, 2007 - 2:36:32 PM
Last modification on : Thursday, April 7, 2022 - 10:10:19 AM

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Clarisse Lorin, Héla Saidi, Afifa Belaid, Amira Zairi, Françoise Baleux, et al.. The antimicrobial peptide dermaseptin S4 inhibits HIV-1 infectivity in vitro.. Virology, Elsevier, 2005, 334 (2), pp.264-75. ⟨10.1016/j.virol.2005.02.002⟩. ⟨pasteur-00166747⟩



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