Service interruption on Monday 11 July from 12:30 to 13:00: all the sites of the CCSD (HAL, EpiSciences, SciencesConf, AureHAL) will be inaccessible (network hardware connection).
Abstract : Poliovirus (PV) is the causal agent of paralytic poliomyelitis, an acute disease of the central nervous system (CNS) resulting in flaccid paralysis. The development of new animal and cell models has allowed the key steps of the pathogenesis of poliomyelitis to be investigated at the molecular level. In particular, it has been shown that PV-induced apoptosis is an important component of the tissue injury in the CNS of infected mice, which leads to paralysis. In this review the molecular biology of PV and the pathogenesis of poliomyelitis are briefly described, and then several models of PV-induced apoptosis are considered; the role of the cellular receptor of PV, CD155, in the modulation of apoptosis is also addressed.
https://hal-pasteur.archives-ouvertes.fr/pasteur-00166736 Contributor : Hélène RibierreConnect in order to contact the contributor Submitted on : Friday, August 17, 2007 - 10:15:50 AM Last modification on : Thursday, April 7, 2022 - 10:10:19 AM Long-term archiving on: : Friday, November 25, 2016 - 4:51:34 PM
File
Restricted access
To satisfy the distribution rights of the publisher, the document is embargoed
until : jamais
B. Blondel, F. Colbère-Garapin, T. Couderc, A. Wirotius, F. Guivel-Benhassine. Poliovirus, pathogenesis of poliomyelitis, and apoptosis.. Diane E. Griffin. Role of Apoptosis in Infection, 289, Springer, pp.25-56, 2005, Current Topics in Microbiology and Immunology, 978-3-540-23006-9. ⟨10.1007/3-540-27320-4_2⟩. ⟨pasteur-00166736⟩