Poliovirus, pathogenesis of poliomyelitis, and apoptosis.

B. Blondel (1) , F. Colbère-Garapin (1) , T. Couderc (2) , A. Wirotius (1) , F. Guivel-Benhassine (3)

1 Virus Entérotropes et Stratégies Antivirales
2 BCI - Département de Biologie cellulaire et infection - Department of Cell Biology and infection
3 Virus et Immunité

Poliovirus (PV) is the causal agent of paralytic poliomyelitis, an acute disease of the central nervous system (CNS) resulting in flaccid paralysis. The development of new animal and cell models has allowed the key steps of the pathogenesis of poliomyelitis to be investigated at the molecular level. In particular, it has been shown that PV-induced apoptosis is an important component of the tissue injury in the CNS of infected mice, which leads to paralysis. In this review the molecular biology of PV and the pathogenesis of poliomyelitis are briefly described, and then several models of PV-induced apoptosis are considered; the role of the cellular receptor of PV, CD155, in the modulation of apoptosis is also addressed.

Keywords: Paralytic Poliomyelitis; Poliovirus Infection; Poliovirus Receptor; Human Fetal Brain Cell; Postpolio Syndrome

Domains: Life Sciences [q-bio]; Microbiology and Parasitology; Virology

B. Blondel, F. Colbère-Garapin, T. Couderc, A. Wirotius, F. Guivel-Benhassine. Poliovirus, pathogenesis of poliomyelitis, and apoptosis.. Diane E. Griffin. Role of Apoptosis in Infection, 289, Springer, pp.25-56, 2005, Current Topics in Microbiology and Immunology, 978-3-540-23006-9. ⟨10.1007/3-540-27320-4_2⟩. ⟨pasteur-00166736⟩