Transmission of Bordetella pertussis to young infants

Aaron Mark Wendelboe (1) , Elisabeth Njamkepo (2) , Antoine Bourillon (3) , Daniel Floret (4) , Joel Gaudelus (5) , Michael Gerber (6) , Emmanuel Grimprel (7) , David A. Greenberg (8) , Scott Halperin (9) , Johannes Liese (10) , Flor Munoz-Rivas (11, 12) , Remy Teyssou (13) , Nicole Guiso (2) , Annelies van Rie (1)

1 UNC - University of North Carolina [Chapel Hill]
2 CNR - Centre National de Référence de la Coqueluche et autres bordetelloses
3 Hôpital Robert Debré Paris
4 UCBL - Université Claude Bernard Lyon 1
5 Hôpital Jean Verdier [AP-HP]
6 Cincinnati Children's Hospital Medical Center
7 CHU Trousseau [APHP]
8 Children's Hospital of Pittsburgh of UPMC [Etats-Unis]
9 Dalhousie University [Halifax]
10 LMU - Ludwig-Maximilians-Universität München
11 BCM - Baylor College of Medicine
12 Texas Children's Hospital [Houston, USA]
13 Sanofi Pasteur [Lyon, France]

BACKGROUND: Pertussis vaccination has reduced the number of notified cases in industrialized countries from peak years by more than 95%. The effect of recently recommended adult and adolescent vaccination strategies on infant pertussis depends, in part, on the proportion of infants infected by adults and adolescents. This proportion, however, remains unclear, because studies have not been able to determine the source case for 47%-60% of infant cases. METHODS: A prospective international multicenter study was conducted of laboratory confirmed infant pertussis cases (aged

Keywords: transmission; source case; sensitivity analysis; diagnosis; asymptomatic

Domains: Santé publique et épidémiologie

Aaron Mark Wendelboe, Elisabeth Njamkepo, Antoine Bourillon, Daniel Floret, Joel Gaudelus, et al.. Transmission of Bordetella pertussis to young infants. Pediatric Infectious Disease Journal, 2007, 26 (4), pp.293-299. ⟨10.1097/01.inf.0000258699.64164.6d⟩. ⟨pasteur-00161884⟩