Skip to Main content Skip to Navigation
Journal articles

Differential expression of regulator of G-protein signalling transcripts and in vivo migration of CD4+ naïve and regulatory T cells.

Abstract : The immune response of T lymphocytes to pathogens is initiated in draining secondary lymphoid organs, and activated cells then migrate to the site of infection. Thus, control of naive and regulatory CD4+ T-cell migration is crucial; however, it is poorly understood in physiological and pathological conditions. We found that CD4+ subpopulations displayed characteristic regulator of G-protein signalling (RGS) gene expression profiles. Regulatory T cells express higher levels of RGS1, RGS9 and RGS16 than naive cells. These genes are up-regulated upon cell activation and their level of expression correlates with in vivo cell migration. Using parabiosis, we showed that regulatory T lymphocytes migrate less than naive T cells and that migrant naive T cells express even lower RGS levels than their static counterparts. Our results show an inverse correlation between the capacity to migrate and the levels of RGS1, RGS9 and RGS16 for both naive and regulatory T cells. Taken together, these results suggest a role for RGS molecules in chemokine-induced lymphocyte migration and demonstrate the peculiarity of regulatory T cells in terms of phenotype and migration ability, providing new insights into their function.
Document type :
Journal articles
Complete list of metadatas

Cited literature [30 references]  Display  Hide  Download

https://hal-pasteur.archives-ouvertes.fr/pasteur-00019857
Contributor : Marie-Christine Vougny <>
Submitted on : Tuesday, October 2, 2007 - 12:01:05 PM
Last modification on : Monday, January 13, 2020 - 5:08:06 PM
Long-term archiving on: : Friday, November 25, 2016 - 10:19:57 AM

File

 Restricted access
To satisfy the distribution rights of the publisher, the document is embargoed until : jamais

Please log in to resquest access to the document

Identifiers

Collections

Citation

Fabien Agenes, Nabil Bosco, Laurent Mascarell, Sabrina Fritah, Rhodri Ceredig. Differential expression of regulator of G-protein signalling transcripts and in vivo migration of CD4+ naïve and regulatory T cells.. Immunology, Wiley, 2007, 115 (2), pp.179-88. ⟨10.1111/j.1365-2567.2005.02146.x⟩. ⟨pasteur-00019857⟩

Share

Metrics

Record views

222