5-ALA induced PpIX fluorescence spectroscopy in neurosurgery: a review

Arthur Gautheron (1, 2) , J. Bernstock (3, 4) , T. Picart (5, 6) , J. Guyotat (5) , P. Valdés (7, 8, 9) , Bruno Montcel (2, 10)

1 LHC - Laboratoire Hubert Curien
2 RMN et optique : De la mesure au biomarqueur
3 Department of Neurosurgery [Boston]
4 David H. Koch Institute for Integrative Cancer Research
5 Service de Neurochirurgie [Hopital Pierre Wertheimer - HCL]
6 UNICANCER/CRCL - Centre de Recherche en Cancérologie de Lyon
7 UTMB - Department of Neurosurgery, UTMB
8 Departement of Neurobiology, UTMB - Departement of Neurobiology, UTMB
9 Electrical and Computer Engineering - Rice University
10 CREATIS - Centre de Recherche en Acquisition et Traitement de l'Image pour la Santé

The review begins with an overview of the fundamental principles/physics underlying light, fluorescence, and other light-matter interactions in biological tissues. It then focuses on 5-aminolevulinic acid (5-ALA)-induced protoporphyrin IX (PpIX) fluorescence spectroscopy methods used in neurosurgery (e.g., intensity, time-resolved) and in so doing, describe their specific features (e.g., hardware requirements, main processing methods) as well as their strengths and limitations. Finally, we review current clinical applications and future directions of 5-ALA-induced protoporphyrin IX (PpIX) fluorescence spectroscopy in neurosurgery.

Domains: Imaging

Arthur Gautheron, J. Bernstock, T. Picart, J. Guyotat, P. Valdés, et al.. 5-ALA induced PpIX fluorescence spectroscopy in neurosurgery: a review. Frontiers in Neuroscience, 2024, 18, ⟨10.3389/fnins.2024.1310282⟩. ⟨hal-04423276⟩