Pedunculopontine and Cuneiform Nuclei Deep Brain Stimulation for Severe Gait and Balance Disorders in Parkinson’s Disease: Interim Results from a Randomized Double-Blind Clinical Trial

Julie Bourilhon (1) , Claire Olivier , Hana You , Antoine Collomb-Clerc , David Grabli , Hayat Belaid , Yannick Mullie , Chantal François , Virginie Czernecki , Brian Lau , Fernando Pérez-García , Eric Bardinet , Sara Fernandez-Vidal , Carine Karachi , Marie-Laure Welter (1)

1 ICM - Institut du Cerveau = Paris Brain Institute

Background: Dopa-resistant freezing of gait (FOG) and falls represent the dominant motor disabilities in advanced Parkinson's disease (PD). Objective: We investigate the effects of deep brain stimulation (DBS) of the mesencephalic locomotor region (MLR), comprised of the pedunculopontine (PPN) and cuneiform (CuN) nuclei, for treating gait and balance disorders, in a randomized double-blind cross-over trial. Methods: Six PD patients with dopa-resistant FOG and/or falls were operated for MLR-DBS. Patients received three DBS conditions, PPN, CuN, or sham, in a randomized order for 2-months each, followed by an open-label phase. The primary outcome was the change in anteroposterior anticipatory-postural-adjustments (APAs) during gait initiation on a force platform

Mots clés: Mesencephalic locomotor region Parkinson's disease patients freezing of gait postural instability deep brain stimulation; Mesencephalic locomotor region; Parkinson's disease patients; freezing of gait; postural instability; deep brain stimulation

Domaines: Planète et Univers [physics]

Julie Bourilhon, Claire Olivier, Hana You, Antoine Collomb-Clerc, David Grabli, et al.. Pedunculopontine and Cuneiform Nuclei Deep Brain Stimulation for Severe Gait and Balance Disorders in Parkinson’s Disease: Interim Results from a Randomized Double-Blind Clinical Trial. 2023. ⟨hal-03579807v1⟩