Welcome to the HAL collection of the 4CS (UR 22751)
4CS Laboratory (Channels and Connexins in Cancer and Cell Stemness), resulting from 4CS team of STIM laboratory (*), is a laboratory from University of Poitiers (UR 22751).
* Browse the HAL collection of the STIM laboratory
The general objectives of 4CS laboratory are to better characterize how ion channels and connexins participate to physiological properties and cellular plasticity in stem cells and invasive cells from different organs. We also aim at investigating, how the pathological remodeling of calcium/connexin signaling promote cancer progression and whether their pathological signaling pathways can be targeted to improve cancer treatment.
Our research projects revolve around two main themes :
- Roles of calcium channels and connexins in the dynamics of stem cells (normal and cancerous) and invasive cancer cells: self-renewal, proliferation, cell migration, dissemination and metastasis formation.
- Involvement of calcium channels and connexin in response/resistance to treatment and development of new therapeutic strategies, based on the modulation of the identified pharmaceutical targets.
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