???Ready made??? virulence and ???dual use??? virulence factors in pathogenic environmental fungi ??? the Cryptococcus neoformans paradigm, Current Opinion in Microbiology, vol.6, issue.4, pp.332-337, 2003. ,
DOI : 10.1016/S1369-5274(03)00082-1
Cryptococcus neoformans interactions with amoebae suggest an explanation for its virulence and intracellular pathogenic strategy in macrophages, Proceedings of the National Academy of Sciences, vol.98, issue.26, pp.15245-15250, 2001. ,
DOI : 10.1073/pnas.261418798
The Transcriptional Response of Cryptococcus neoformans to Ingestion by Acanthamoeba castellanii and Macrophages Provides Insights into the Evolutionary Adaptation to the Mammalian Host, Eukaryotic Cell, vol.12, issue.5, pp.761-774, 2013. ,
DOI : 10.1128/EC.00073-13
Phenotypic switching of Cryptococcus neoformans occurs in vivo and influences the outcome of infection, Journal of Clinical Investigation, vol.108, issue.11, pp.1639-1648, 2001. ,
DOI : 10.1172/JCI13407
Catch me if you can: phagocytosis and killing avoidance by Cryptococcus neoformans, FEMS Immunology & Medical Microbiology, vol.64, issue.2, pp.147-161, 2012. ,
DOI : 10.1111/j.1574-695X.2011.00871.x
Evidence of a Role for Monocytes in Dissemination and Brain Invasion by Cryptococcus neoformans, Infection and Immunity, vol.77, issue.1, pp.120-127, 2009. ,
DOI : 10.1128/IAI.01065-08
Role of Extracellular Phospholipases and Mononuclear Phagocytes in Dissemination of Cryptococcosis in a Murine Model, Infection and Immunity, vol.72, issue.4, pp.2229-2239, 2004. ,
DOI : 10.1128/IAI.72.4.2229-2239.2004
Estimation of the current global burden of cryptococcal meningitis among persons living with HIV/AIDS, AIDS, vol.23, issue.4, pp.525-530, 2009. ,
DOI : 10.1097/QAD.0b013e328322ffac
Cryptococcus neoformans, 1998. ,
DOI : 10.1128/9781555818241
Determinants of Disease Presentation and Outcome during Cryptococcosis: The CryptoA/D Study, PLoS Medicine, vol.21, issue.2, 2007. ,
DOI : 10.1371/journal.pmed.0040021.sd002
Expanding fungal pathogenesis: Cryptococcus breaks out of the opportunistic box, Nature Reviews Microbiology, vol.4, issue.3, pp.193-203, 2011. ,
DOI : 10.1038/nrmicro2522
Serologic Evidence for Cryptococcus neoformans Infection in Early Childhood, PEDIATRICS, vol.107, issue.5, p.66, 2001. ,
DOI : 10.1542/peds.107.5.e66
The Primary Pulmonary Lymph Node Complex of Cryptococcosis, American Journal of Clinical Pathology, vol.65, issue.1, pp.83-92, 1976. ,
DOI : 10.1093/ajcp/65.1.83
Cryptococcus neoformans: Latency and Disease. Cryptococcus: From Human Pathogen to Model Yeast, p.429, 2010. ,
Epidemiological evidence for dormant Cryptococcus neoformans infection, J Clin Microbiol, vol.37, pp.3204-3209, 1999. ,
Isolation of Cryptococcus neoformans var. gattii ! murine macrophages and enhances fungal survival, Infect Immun, vol.77, pp.2783-2794, 1992. ,
Cryptococcus neoformans Is Resistant to Surfactant Protein A Mediated Host Defense Mechanisms, PLoS ONE, vol.172, issue.(Pt 3), 2007. ,
DOI : 10.1371/journal.pone.0001370.g005
Aggregation of Cryptococcus neoformans by Surfactant Protein D Is Inhibited by Its Capsular Component Glucuronoxylomannan, Infection and Immunity, vol.72, issue.1, pp.145-153, 2004. ,
DOI : 10.1128/IAI.72.1.145-153.2004
Pulmonary surfactant protein A binds to Cryptococcus neoformans without promoting phagocytosis, European Journal of Clinical Investigation, vol.23, issue.1, pp.83-92, 1999. ,
DOI : 10.1016/0166-0934(93)90164-M
Surfactant Protein D Facilitates Cryptococcus neoformans Infection, Infection and Immunity, vol.80, issue.7, pp.2444-2453, 2012. ,
DOI : 10.1128/IAI.05613-11
Elucidating the Pathogenesis of Spores from the Human Fungal Pathogen Cryptococcus neoformans, Infection and Immunity, vol.77, issue.8, pp.3491-3500, 2009. ,
DOI : 10.1128/IAI.00334-09
Role of the Mannose Receptor in a Murine Model of Cryptococcus neoformans Infection, Infection and Immunity, vol.76, issue.6, pp.2362-2367, 2008. ,
DOI : 10.1128/IAI.00095-08
Inhibition of phagocytosis by cryptococcal polysaccharide: dissociation of the attachment and ingestion phases of phagocytosis, Infect Immun, vol.14, pp.62-67, 1976. ,
Cryptococcus neoformans. 3. Inhibition of phagocytosis, J Bacteriol, vol.95, pp.5-8, 1968. ,
The capsule of Cryptococcus neoformans passively inhibits phagocytosis of the yeast by macrophages, J Immunol, vol.129, pp.1675-1680, 1982. ,
Ingestion of acapsular Cryptococcus neoformans occurs via mannose and beta-glucan receptors, resulting in cytokine production and increased phagocytosis of the encapsulated form, Infect Immun, vol.63, pp.2604-2611, 1995. ,
Identification of App1 as a regulator of phagocytosis and virulence of Cryptococcus neoformans, Journal of Clinical Investigation, vol.112, issue.7, pp.1080-1094, 2003. ,
DOI : 10.1172/JCI18309
App1: An Antiphagocytic Protein That Binds to Complement Receptors 3 and 2, The Journal of Immunology, vol.182, issue.1, pp.84-91, 2009. ,
DOI : 10.4049/jimmunol.182.1.84
Systematic Genetic Analysis of Virulence in the Human Fungal Pathogen Cryptococcus neoformans, Cell, vol.135, issue.1, pp.174-188, 2008. ,
DOI : 10.1016/j.cell.2008.07.046
A Major Role for Capsule-Independent Phagocytosis-Inhibitory Mechanisms in Mammalian Infection by Cryptococcus neoformans, Cell Host & Microbe, vol.9, issue.3, 2011. ,
DOI : 10.1016/j.chom.2011.02.003
Fungal cell gigantism during mammalian infection, PLoS Pathog, vol.6, 2010. ,
Cryptococcal cell morphology affects host cell interactions and pathogenicity, PLoS Pathog, vol.6, 2010. ,
Titan Cells Confer Protection from Phagocytosis in Cryptococcus neoformans Infections, Eukaryotic Cell, vol.11, issue.6, pp.820-826, 2012. ,
DOI : 10.1128/EC.00121-12
Replication of Cryptococcus neoformans in macrophages is accompanied by phagosomal permeabilization and accumulation of vesicles containing polysaccharide in the cytoplasm, Proceedings of the National Academy of Sciences, vol.99, issue.5, pp.3165-3170, 2002. ,
DOI : 10.1073/pnas.052702799
Cytokine Signaling Regulates the Outcome of Intracellular Macrophage Parasitism by Cryptococcus neoformans, Infection and Immunity, vol.77, issue.8, pp.3450-3457, 2009. ,
DOI : 10.1128/IAI.00297-09
Cryptococcus neoformans resides in an acidic phagolysosome of human macrophages, Infect Immun, vol.67, pp.885-890, 1999. ,
Cryptococcus neoformans Enters the Endolysosomal Pathway of Dendritic Cells and Is Killed by Lysosomal Components, Infection and Immunity, vol.76, issue.10, pp.4764-4771, 2008. ,
DOI : 10.1128/IAI.00660-08
Cryptococcus neoformans, a fungus under stress, Current Opinion in Microbiology, vol.10, issue.4, pp.320-325, 2007. ,
DOI : 10.1016/j.mib.2007.05.014
Quantitative analysis of phagocytosis and killing of Cryptococcus neoformans by human peripheral blood mononuclear cells by flow cytometry, Clin Diagn Lab Immunol, vol.2, pp.753-759, 1995. ,
Killing of Cryptococcus neoformans strains by human neutrophils and monocytes, Infect Immun, vol.59, pp.24-28, 1991. ,
Factors Influencing Killing of Cryptococcus neoformans by Human Leukocytes In Vitro, Journal of Infectious Diseases, vol.125, issue.4, pp.367-376, 1972. ,
DOI : 10.1093/infdis/125.4.367
How nascent phagosomes mature to become phagolysosomes, Trends in Immunology, vol.33, issue.8, pp.397-405, 2012. ,
DOI : 10.1016/j.it.2012.03.003
Paradoxical role of capsule in murine bronchoalveolar macrophage-mediated killing of Cryptococcus neoformans, J Immunol, vol.142, pp.659-665, 1989. ,
Fungicidal activity of IFN-gammaactivated macrophages. Extracellular killing of Cryptococcus neoformans, J Immunol, vol.142, pp.3219-3224, 1989. ,
Cryptococcus neoformans Virulence Is Enhanced after Growth in the Genetically Malleable Host Dictyostelium discoideum, Infection and Immunity, vol.71, issue.9, pp.4862-4872, 2003. ,
DOI : 10.1128/IAI.71.9.4862-4872.2003
Nonlinear partial differential equations and applications: Killing of Caenorhabditis elegans by Cryptococcus neoformans as a model of yeast pathogenesis, Proceedings of the National Academy of Sciences, vol.99, issue.24, pp.15675-15680, 2002. ,
DOI : 10.1073/pnas.232568599
Phagosome Extrusion and Host-Cell Survival after Cryptococcus neoformans Phagocytosis by Macrophages, Current Biology, vol.16, issue.21, pp.2161-2165, 2006. ,
DOI : 10.1016/j.cub.2006.09.061
Expulsion of Live Pathogenic Yeast by Macrophages, Current Biology, vol.16, issue.21, pp.2156-2160, 2006. ,
DOI : 10.1016/j.cub.2006.09.032
The Outcome of Phagocytic Cell Division with Infectious Cargo Depends on Single Phagosome Formation, PLoS ONE, vol.33, issue.5, 2008. ,
DOI : 10.1371/journal.pone.0003219.s009
Nonlytic Exocytosis of Cryptococcus neoformans from Macrophages Occurs In Vivo and Is Influenced by Phagosomal pH, mBio, vol.2, issue.4, pp.167-178, 2011. ,
DOI : 10.1128/mBio.00167-11
Non-lytic expulsion/exocytosis of Candida albicans from macrophages, Fungal Genetics and Biology, vol.49, issue.9, pp.677-678, 2012. ,
DOI : 10.1016/j.fgb.2012.01.008
The Human Fungal Pathogen Cryptococcus neoformans Escapes Macrophages by a Phagosome Emptying Mechanism That Is Inhibited by Arp2/3 Complex-Mediated Actin Polymerisation, PLoS Pathogens, vol.74, issue.8, 2010. ,
DOI : 10.1371/journal.ppat.1001041.s016
SEC14 is a specific requirement for secretion of phospholipase B1 and pathogenicity of Cryptococcus neoformans, Molecular Microbiology, vol.69, issue.2, 2011. ,
DOI : 10.1111/j.1365-2958.2011.07632.x
Cell-to-cell spread and massive vacuole formation after Cryptococcus neoformans infection of murine macrophages, BMC Immunology, vol.8, issue.1, pp.16-26, 2007. ,
DOI : 10.1186/1471-2172-8-16
Direct cell-to-cell spread of a pathogenic yeast, BMC Immunology, vol.8, issue.1, pp.15-25, 2007. ,
DOI : 10.1186/1471-2172-8-15
Cryptococcus neoformans survive and replicate in human microglia, Lab Invest, vol.73, pp.871-879, 1995. ,
Capsular polysaccharides galactoxylomannan and glucuronoxylomannan from Cryptococcus neoformans induce macrophage apoptosis mediated by Fas ligand, Cellular Microbiology, vol.153, issue.6, pp.1274-1285, 2008. ,
DOI : 10.1038/15260
Galactoxylomannan-Mediated Immunological Paralysis Results from Specific B Cell Depletion in the Context of Widespread Immune System Damage, The Journal of Immunology, vol.183, issue.6, pp.3885-3894, 2009. ,
DOI : 10.4049/jimmunol.0900449
SEROLOGIC EVIDENCE FOR REGIONAL DIFFERENCES IN PEDIATRIC CRYPTOCOCCAL INFECTION, The Pediatric Infectious Disease Journal, vol.26, issue.6, pp.549-551, 2007. ,
DOI : 10.1097/INF.0b013e318047e073
Experience with a new skin test antigen prepared from Cryptococcus neoformans, Am Rev Respir Dis, vol.97, pp.637-643, 1968. ,
Serologic Evidence for Reactivation of Cryptococcosis in Solid-Organ Transplant Recipients, Clinical and Vaccine Immunology, vol.14, issue.12, pp.1550-1554, 2007. ,
DOI : 10.1128/CVI.00242-07
Cryptococcal Meningitis after Unusual Exposures to Birds, New England Journal of Medicine, vol.328, issue.18, pp.1354-1355, 1993. ,
DOI : 10.1056/NEJM199305063281816
Evidence of Zoonotic Transmission of Cryptococcus neoformans from a Pet Cockatoo to an Immunocompromised Patient, Annals of Internal Medicine, vol.132, issue.3, pp.205-208, 2000. ,
DOI : 10.7326/0003-4819-132-3-200002010-00006
Pneumonia due to Cryptococcus neoformans in a patient receiving infliximab: possible zoonotic transmission from a pet cockatiel, Respir Care, vol.49, pp.606-608, 2004. ,
Pulmonary cryptococcosis, Semin Respir Crit Care Med, vol.25, pp.145-157, 2004. ,
Primary pulmonary cryptococcosis, Am Rev Respir Dis, vol.94, pp.236-243, 1966. ,
Primary Cutaneous Cryptococcosis: A Distinct Clinical Entity, Clinical Infectious Diseases, vol.36, issue.3, pp.337-347, 2003. ,
DOI : 10.1086/345956
Asymptomatic serum cryptococcal antigenemia and early mortality during antiretroviral therapy in r u r a l U g a n d a . Tr o p M e d I n t H e a l t, pp.1365-3156, 2007. ,
Prevalence and Outcomes of Cryptococcal Antigenemia in HIV-Seropositive Patients Hospitalized for Suspected Tuberculosis in Uganda, JAIDS Journal of Acquired Immune Deficiency Syndromes, vol.63, issue.2, pp.189-194, 2013. ,
DOI : 10.1097/QAI.0b013e3182926f95
Prevalence, Determinants of Positivity, and Clinical Utility of Cryptococcal Antigenemia in Cambodian HIV-Infected Patients, JAIDS Journal of Acquired Immune Deficiency Syndromes, vol.45, issue.5, pp.555-559, 2007. ,
DOI : 10.1097/QAI.0b013e31811ed32c
Cryptococcal Antigen Screening and Preemptive Therapy in Patients Initiating Antiretroviral Therapy in Resource-Limited Settings: A Proposed Algorithm for Clinical Implementation, Journal of the International Association of Physicians in AIDS Care (JIAPAC), vol.11, issue.6, pp.374-379, 2012. ,
DOI : 10.1177/1545109712459077
Clinical Practice Guidelines for the Management of Cryptococcal Disease: 2010 Update by the Infectious Diseases Society of America, Clinical Infectious Diseases, vol.50, issue.3, pp.291-322, 2010. ,
DOI : 10.1086/649858
Genotypes Coding for Mannose-Binding Lectin Deficiency Correlated With Cryptococcal Meningitis in HIV-Uninfected Chinese Patients, Journal of Infectious Diseases, vol.203, issue.11, pp.1686-1691, 2011. ,
DOI : 10.1093/infdis/jir152
The Cryptococcus neoformans Capsule: a Sword and a Shield, Clinical Microbiology Reviews, vol.25, issue.3, pp.387-408, 2012. ,
DOI : 10.1128/CMR.00001-12
Temperature-Regulated Transcription in the Pathogenic Fungus Cryptococcus neoformans, Genome Research, vol.12, issue.9, pp.1386-1400, 2002. ,
DOI : 10.1101/gr.80202
Cryptococcus neoformans melanin and virulence: mechanism of action, Infect Immun, vol.63, pp.3131-3136, 1995. ,
galactoxylomannan is a potent negative immunomodulator, inspiring new approaches in anti-inflammatory immunotherapy, Immunotherapy, vol.3, issue.8, pp.997-1005, 2011. ,
DOI : 10.2217/imt.11.86
Extracellular phospholipase activity is a virulence factor for Cryptococcus neoformans, Molecular Microbiology, vol.153, issue.1, pp.166-175, 2001. ,
DOI : 10.1111/j.1574-6968.1994.tb07257.x
Urease as a Virulence Factor in Experimental Cryptococcosis, Infection and Immunity, vol.68, issue.2, pp.443-448, 2000. ,
DOI : 10.1128/IAI.68.2.443-448.2000
Superoxide Dismutase Influences the Virulence of Cryptococcus neoformans by Affecting Growth within Macrophages, Infection and Immunity, vol.71, issue.1, pp.173-180, 2003. ,
DOI : 10.1128/IAI.71.1.173-180.2003
Phagocytosis and Protein Processing Are Required for Presentation of Cryptococcus neoformans Mitogen to T Lymphocytes, Infection and Immunity, vol.68, issue.11, pp.6147-6153, 2000. ,
DOI : 10.1128/IAI.68.11.6147-6153.2000
Vesicular transport across the fungal cell wall, Trends in Microbiology, vol.17, issue.4, pp.158-162, 2009. ,
DOI : 10.1016/j.tim.2008.12.005
Extracellular Vesicles from Cryptococcus neoformans Modulate Macrophage Functions, Infection and Immunity, vol.78, issue.4, pp.1601-1609, 2010. ,
DOI : 10.1128/IAI.01171-09
: Gastronomic delight of a soil ameba, Medical Mycology, vol.17, issue.3, pp.225-232, 1979. ,
DOI : 10.1080/00362177985380341
Microorganisms Resistant to Free-Living Amoebae, Clinical Microbiology Reviews, vol.17, issue.2, pp.413-433, 2004. ,
DOI : 10.1128/CMR.17.2.413-433.2004
Phagocytic and destructive action of Hartmanella castellanii (Amoeba castellanii) on pathogenic encapsulated yeast-like fungi Torulopsis neoformans (Cryptococcus neoformans)], Ann Inst Pasteur, vol.89, pp.1-7, 1955. ,
Challenge of Drosophila melanogaster with Cryptococcus neoformans and Role of the Innate Immune Response, Eukaryotic Cell, vol.3, issue.2, pp.413-419, 2004. ,
DOI : 10.1128/EC.3.2.413-419.2004
The pursuit of cryptococcal pathogenesis: heterologous hosts and the study of cryptococcal host???pathogen interactions, FEMS Yeast Research, vol.0, issue.0, pp.567-573, 2006. ,
DOI : 10.1111/j.1567-1364.2005.00056.x
Pathogenesis of pulmonary Cryptococcus neoformans infection in the rat, Infect Immun, vol.62, pp.4755-4761, 1994. ,
The Relative Susceptibility of Mouse Strains to Pulmonary Cryptococcus neoformans Infection Is Associated with Pleiotropic Differences in the Immune Response, Infection and Immunity, vol.75, issue.6, pp.2729-2739, 2007. ,
DOI : 10.1128/IAI.00094-07
Do Kinetics of the Humoral Response to Cryptococcus neoformans Proteins during Murine Cryptococcosis Reflect Outcome?, Infection and Immunity, vol.68, issue.6, pp.3724-3726, 2000. ,
DOI : 10.1128/IAI.68.6.3724-3726.2000
Adaptation of Cryptococcus neoformans to Mammalian Hosts: Integrated Regulation of Metabolism and Virulence, Eukaryotic Cell, vol.11, issue.2, pp.109-118, 2012. ,
DOI : 10.1128/EC.05273-11
Cryptococcus neoformans and Cryptococcus gattii genes preferentially expressed, pp.9-12, 2010. ,
Transcriptional Response of Candida albicans upon Internalization by Macrophages, Eukaryotic Cell, vol.3, issue.5, pp.1076-1087, 2004. ,
DOI : 10.1128/EC.3.5.1076-1087.2004
X-Linked Immunodeficient Mice Exhibit Enhanced Susceptibility to Cryptococcus neoformans Infection, mBio, vol.4, issue.4, pp.265-278, 2013. ,
DOI : 10.1128/mBio.00265-13
Cryptococcus neoformans Antibody Levels in Patients with AIDS, Scandinavian Journal of Infectious Diseases, vol.101, issue.3, pp.283-285, 1988. ,
DOI : 10.3109/00365548809032452
Ab binding alters gene expression in Cryptococcus neoformans and directly modulates fungal metabolism, Journal of Clinical Investigation, vol.120, issue.4, pp.1355-1361, 2010. ,
DOI : 10.1172/JCI38322DS1
AD Hybrid Strains, G3: Genes|Genomes|Genetics, vol.2, issue.1, pp.83-97, 2012. ,
DOI : 10.1534/g3.111.001255
Comparative gene genealogical analyses of strains of serotype AD identify recombination in populations of serotypes A and D in the human pathogenic yeast Cryptococcus neoformans, Microbiology, vol.149, issue.8, pp.2147-2154, 2003. ,
DOI : 10.1099/mic.0.26180-0
Deciphering the Model Pathogenic Fungus Cryptococcus Neoformans, Nature Reviews Microbiology, vol.152, issue.1, pp.753-764, 1245. ,
DOI : 10.1111/j.1365-2958.2004.03921.x
Multilocus Sequence Typing Reveals Three Genetic Subpopulations of Cryptococcus neoformans var. grubii (Serotype A), Including a Unique Population in Botswana, Genetics, vol.172, issue.4, pp.2223-2238, 2006. ,
DOI : 10.1534/genetics.105.046672
Phagocytosis of Cryptococcus neoformans by, and Nonlytic Exocytosis from, Acanthamoeba castellanii, Applied and Environmental Microbiology, vol.76, issue.18, pp.6056-6062, 2010. ,
DOI : 10.1128/AEM.00812-10
Galleria mellonella as a Model System To Study Cryptococcus neoformans Pathogenesis, Infection and Immunity, vol.73, issue.7, 2005. ,
DOI : 10.1128/IAI.73.7.3842-3850.2005
Pathogenicity of basidiospores of Filobasidiella neoformans var. neoformans, Med Mycol, vol.36, pp.419-424, 1998. ,
Spores as Infectious Propagules of Cryptococcus neoformans, Infection and Immunity, vol.77, issue.10, pp.4345-4355, 2009. ,
DOI : 10.1128/IAI.00542-09
[Contributions to the strain-specific virulence of Cryptococcus neoformans Animal experiments with two C. neoformans-strains isolated from bird manure. Preliminary report (author's transl)], Zentralbl Bakteriol Orig A, vol.230, pp.81-85, 1975. ,
Virulence of Cryptococcus neoformans serotypes A, B, C and D for four mouse strains, Journal of Medical Microbiology, vol.43, issue.4, pp.289-293, 1995. ,
DOI : 10.1099/00222615-43-4-289
The Primary Target Organ of Cryptococcus gattii Is Different from That of Cryptococcus neoformans in a Murine Model, mBio, vol.3, issue.3, 2012. ,
DOI : 10.1128/mBio.00103-12
A Diverse Population of Cryptococcus gattii Molecular Type VGIII in Southern Californian HIV/AIDS Patients, PLoS Pathogens, vol.16, issue.9, 2011. ,
DOI : 10.1371/journal.ppat.1002205.s012
by rat alveolar macrophages, Medical Mycology, vol.27, issue.4, pp.203-217, 1989. ,
DOI : 10.1080/02681218980000291
Strain variation in phagocytosis of Cryptococcus neoformans: dissociation of susceptibility to phagocytosis from activation and binding of opsonic fragments of C3, Infect Immun, vol.56, pp.2794-2800, 1988. ,
by rat alveolar macrophages, Medical Mycology, vol.27, issue.4, pp.219-228, 1989. ,
DOI : 10.1080/02681218980000301
Direct activity of human T lymphocytes and natural killer cells against Cryptococcus neoformans, Infect Immun, vol.62, pp.194-202, 1994. ,
Emergence and Pathogenicity of Highly Virulent Cryptococcus gattii Genotypes in the Northwest United States, PLoS Pathogens, vol.11, issue.4, 2010. ,
DOI : 10.1371/journal.ppat.1000850.s010
Cryptococcal Interactions with the Host Immune System, Eukaryotic Cell, vol.9, issue.6, pp.835-84600039, 2010. ,
DOI : 10.1128/EC.00039-10
Role of a VPS41 homologue in starvation response, intracellular survival and virulence of Cryptococcus neoformans, Molecular Microbiology, vol.18, issue.5, pp.1132-1146, 2006. ,
DOI : 10.1046/j.1365-2958.2003.03340.x
PI3K signaling of autophagy is required for starvation tolerance and virulenceof Cryptococcus neoformans, Journal of Clinical Investigation, vol.118, issue.3, pp.1186-1197, 2008. ,
DOI : 10.1172/JCI32053
The DEAD-box RNA helicase Vad1 regulates multiple virulence-associated genes in Cryptococcus neoformans, Journal of Clinical Investigation, vol.115, issue.3, pp.632-641, 2005. ,
DOI : 10.1172/JCI23048DS1
Roles for inositol-phosphoryl ceramide synthase 1 (IPC1) in pathogenesis of C. neoformans, Genes & Development, vol.15, issue.2, pp.201-212, 2001. ,
DOI : 10.1101/gad.856001
Production, characterization, and antibody specificity of a mouse monoclonal antibody reactive with Cryptococcus neoformans capsular polysaccharide, Infect Immun, vol.55, pp.742-748, 1987. ,
Evaluation of fluorescent dyes for measuring intracellular glutathione content in primary cultures of human neurons and neuroblastoma SH-SY5Y, Cytometry Part A, vol.52, issue.1, pp.16-25, 2003. ,
DOI : 10.1002/cyto.a.10003
The Depletion of Nuclear Glutathione Impairs Cell Proliferation in 3t3 Fibroblasts, PLoS ONE, vol.84, issue.3, 2009. ,
DOI : 10.1371/journal.pone.0006413.t002
Bacterial and H2O2 stress-induced apoptosis-like events in Cryptococcus neoformans, Research in Microbiology, vol.159, issue.9-10, pp.628-634, 2008. ,
DOI : 10.1016/j.resmic.2008.07.006
Serological, electrophoretic, and biological properties of Cryptococcus neoformans antigens, Infect Immun, vol.56, pp.424-431, 1988. ,
Culture Media and Reagents. Medical mycology, p.816, 1992. ,
The Human Fungal Pathogen Cryptococcus Can Complete Its Sexual Cycle during a Pathogenic Association with Plants, Cell Host & Microbe, vol.1, issue.4, 2007. ,
DOI : 10.1016/j.chom.2007.05.005
Role of an expanded inositol transporter repertoire in Cryptococcus neoformans sexual reproduction and virulence. mBio 1. doi:10, pp.84-94, 1128. ,
A new mathematical model for relative quantification in real-time RT-PCR, Nucleic Acids Research, vol.29, issue.9, p.45, 2001. ,
DOI : 10.1093/nar/29.9.e45
qBase relative quantification framework and software for management and automated analysis of real-time quantitative PCR data, Genome Biol, vol.8, 2007. ,
TM4: a free, open-source system for microarray data management and analysis, BioTechniques, vol.34, pp.374-378, 2003. ,
Statistical evaluation of mathematical models for microbial growth, International Journal of Food Microbiology, vol.96, issue.3, pp.289-300, 2004. ,
DOI : 10.1016/j.ijfoodmicro.2004.03.026
Characterizing the role of RNA silencing components in Cryptococcus neoformans, Fungal Genetics and Biology, vol.47, issue.12, 2010. ,
DOI : 10.1016/j.fgb.2010.10.005
Laccase and melanin in the pathogenesis of Cryptococcus neoformans, Frontiers in Bioscience, vol.2, issue.5, pp.99-107, 1997. ,
DOI : 10.2741/A231
Regulation of cytochrome c oxidase subunit 1 (COX1) expression in Cryptococcus neoformans by temperature and host environment, Microbiology, vol.149, issue.4, pp.1041-1049, 2003. ,
DOI : 10.1099/mic.0.26021-0
Cryptococcosis in Experimental Animals: Lessons Learned. Cryptococcus: From Human Pathogen to Model Yeast, pp.473-488, 2010. ,
NK Cells Use Perforin Rather than Granulysin for Anticryptococcal Activity, The Journal of Immunology, vol.173, issue.5, pp.3357-3365, 2004. ,
DOI : 10.4049/jimmunol.173.5.3357
Physical Maps for Genome Analysis of Serotype A and D Strains of the Fungal Pathogen Cryptococcus neoformans, Genome Research, vol.12, issue.9, pp.1445-1453, 2002. ,
DOI : 10.1101/gr.81002
Antibody Interactions with the Capsule of Cryptococcus neoformans, Infection and Immunity, vol.68, issue.6, pp.3642-3650, 2000. ,
DOI : 10.1128/IAI.68.6.3642-3650.2000
Cryptococcus neoformans Capsule Structure Evolution In Vitro and during Murine Infection, Infection and Immunity, vol.72, issue.6, pp.3359-3365, 2004. ,
DOI : 10.1128/IAI.72.6.3359-3365.2004
Comparative Genomics of Serial Isolates of Cryptococcus neoformans Reveals Gene Associated with Carbon Utilization and Virulence. G3 (Bethesda), 2013. ,
Cytology and ultrastructure of yeasts and yeastlike fungi. The yeasts, a taxonomic study, p.33, 1998. ,
Wall structure and bud formation inCryptococcus neoformans, Archives of Microbiology, vol.7, issue.1, pp.205-212, 1974. ,
DOI : 10.1007/BF02451762
Comparison of chitin localization in Saccharomyces cerevisiae, Cryptococcus neoformans, and Malassezia spp., Mycological Research, vol.93, issue.4, pp.551-553, 1989. ,
DOI : 10.1016/S0953-7562(89)80053-X
High-content screening in infectious diseases, Current Opinion in Chemical Biology, vol.15, issue.4, pp.534-539, 2011. ,
DOI : 10.1016/j.cbpa.2011.05.023
Identification of Host-Dependent Survival Factors for Intracellular Mycobacterium tuberculosis through an siRNA Screen, PLoS Pathogens, vol.13, issue.4, 2010. ,
DOI : 10.1371/journal.ppat.1000839.s008
A Combination of Flow Cytometry and Traditional Screening Using Chemicals to Isolate High Glutathione-Producing Yeast Mutants, Bioscience, Biotechnology, and Biochemistry, vol.76, issue.6, pp.1085-1090, 2012. ,
DOI : 10.1271/bbb.110883
Glutathione depletion in the ! yeast Saccharomyces cerevisiae, Biochem Mol Biol Int, vol.38, pp.901-910, 1996. ,
Menadione toxicity in Saccharomyces cerevisiae cells: Activation by conjugation with glutathione, IUBMB Life, vol.44, issue.4, pp.747-759, 1998. ,
DOI : 10.1080/15216549800201792
Amphotericin B mediates killing in Cryptococcus neoformans through the induction of a strong oxidative burst, Microbes and Infection, vol.13, issue.5, pp.457-467, 2011. ,
DOI : 10.1016/j.micinf.2011.01.015
Accurate RT-qPCR gene expression analysis on cell culture lysates, Scientific Reports, vol.3, 2012. ,
DOI : 10.1038/srep00222
Dependence of Macrophage Phagocytic Efficacy on Antibody Concentration, Infection and Immunity, vol.75, issue.4, pp.1904-1915, 2007. ,
DOI : 10.1128/IAI.01258-06
Innate Recognition of Fungal Cell Walls, PLoS Pathogens, vol.2, issue.4, 2010. ,
DOI : 10.1371/journal.ppat.1000758.t001
Microevolution of a standard strain of Cryptococcus neoformans resulting in differences in virulence and other phenotypes, Infect Immun, vol.66, pp.89-97, 1998. ,
Property Differences among the Four Major Candida albicans Strain Clades, Eukaryotic Cell, vol.8, issue.3, pp.373-387, 2009. ,
DOI : 10.1128/EC.00387-08
dense granule protein, The Journal of Experimental Medicine, vol.132, issue.1, pp.195-212, 2011. ,
DOI : 10.1084/jem.20091703
Heterogeneity of Wild Leishmania major Isolates in Experimental Murine Pathogenicity and Specific Immune Response, Infection and Immunity, vol.69, issue.8, pp.4906-4915, 2001. ,
DOI : 10.1128/IAI.69.8.4906-4915.2001
Virulence and pathogenicity patterns of Trypanosoma brucei gambiense field isolates in experimentally infected mouse: differences in host immune response modulation by secretome and proteomics, Microbes and Infection, vol.10, issue.1, pp.79-86, 2008. ,
DOI : 10.1016/j.micinf.2007.10.008
Invasion Profiles of Brazilian Field Isolates of Plasmodium falciparum: Phenotypic and Genotypic Analyses, Infection and Immunity, vol.72, issue.10, pp.5886-5891, 2004. ,
DOI : 10.1128/IAI.72.10.5886-5891.2004
Real-time imaging of trapping and urease-dependent transmigration of Cryptococcus neoformans in mouse brain, Journal of Clinical Investigation, vol.120, issue.5, 2010. ,
DOI : 10.1172/JCI41963DS1
Cryptococci at the brain gate: break and enter or use a Trojan horse?, Journal of Clinical Investigation, vol.120, issue.5, pp.1389-1392, 2010. ,
DOI : 10.1172/JCI42949
Investigating clinical cryptococcosis in the context of phagocyte-Cryptococcus interactions, 2012. ,
Cryptococcus neoformans Ex Vivo Capsule Size Is Associated With Intracranial Pressure and Host Immune Response in HIV-associated Cryptococcal Meningitis, Journal of Infectious Diseases, vol.209, issue.1, 2013. ,
DOI : 10.1093/infdis/jit435
Baseline Correlation and Comparative Kinetics of Cerebrospinal Fluid Colony???Forming Unit Counts and Antigen Titers in Cryptococcal Meningitis, The Journal of Infectious Diseases, vol.192, issue.4, pp.681-684, 2005. ,
DOI : 10.1086/432073
Relationship of cerebrospinal fluid pressure, fungal burden and outcome in patients with cryptococcal meningitis undergoing serial lumbar punctures, AIDS, vol.23, pp.701-706, 2009. ,
DOI : 10.1097/QAD.0b013e32832605fe
Fungemia during murine cryptococcosis sheds some light on pathophysiology, Med Mycol, vol.37, pp.169-174, 1999. ,
Capsule Structure Changes Associated with Cryptococcus neoformans Crossing of the Blood-Brain Barrier, The American Journal of Pathology, vol.166, issue.2, pp.421-432, 2005. ,
DOI : 10.1016/S0002-9440(10)62265-1
Titan cells in Cryptococcus neoformans: cells with a giant impact, Current Opinion in Microbiology, vol.16, issue.4, 2013. ,
DOI : 10.1016/j.mib.2013.03.006
Exit from dormancy in microbial organisms, Nature Reviews Microbiology, vol.4, issue.12, pp.890-896, 2010. ,
DOI : 10.1038/nrmicro2453
Lie: Does Dormancy Play a Role in Tuberculosis?, Annual Review of Microbiology, vol.64, issue.1, pp.293-311, 2010. ,
DOI : 10.1146/annurev.micro.112408.134043
Characterization and Transcriptome Analysis of Mycobacterium tuberculosis Persisters, mBio, vol.2, issue.3, pp.100-111, 2011. ,
DOI : 10.1128/mBio.00100-11
Identification of gene targets against dormant phase Mycobacterium tuberculosis infections, BMC Infectious Diseases, vol.30, issue.3, pp.10-1186, 2007. ,
DOI : 10.1093/nar/30.1.42
The hypnozoite concept, with particular reference to malaria, Parasitology Research, vol.4, issue.4, pp.247-252, 2011. ,
DOI : 10.1007/s00436-010-2072-y
"Sleeping Beauty": Quiescence in Saccharomyces cerevisiae, Microbiology and Molecular Biology Reviews, vol.68, issue.2, pp.187-206, 2004. ,
DOI : 10.1128/MMBR.68.2.187-206.2004
Unrepaired oxidative DNA damage induces an ATR/ATM apoptotic-like response in quiescent fission yeast, Cell Cycle, vol.8, issue.15, pp.2326-2331, 2009. ,
DOI : 10.4161/cc.8.15.9147
Transcriptomic analysis of the exit from dormancy of Aspergillus fumigatus conidia, BMC Genomics, vol.9, issue.1, pp.417-427, 2008. ,
DOI : 10.1186/1471-2164-9-417
Long-oligomer microarray profiling in Neurospora crassa reveals the transcriptional program underlying biochemical and physiological events of conidial germination, Nucleic Acids Research, vol.33, issue.20, pp.6469-6485, 2005. ,
DOI : 10.1093/nar/gki953
Dueling in the lung: how Cryptococcus spores race the host for survival, Current Opinion in Microbiology, vol.13, issue.4, pp.437-442, 2010. ,
DOI : 10.1016/j.mib.2010.05.003
Staying alive, Cell Cycle, vol.45, issue.9, pp.1680-1696, 2012. ,
DOI : 10.1038/nature10600
Physiological and genome-wide transcriptional responses of to high carbon dioxide concentrations, FEMS Yeast Research, vol.5, issue.6-7, pp.579-593, 2005. ,
DOI : 10.1016/j.femsyr.2004.09.009
Cryptococcus neoformans Requires a Functional Glycolytic Pathway for Disease but Not Persistence in the Host, mBio, vol.2, issue.3, 2011. ,
DOI : 10.1128/mBio.00103-11
Hypoxia and fungal REFERENCES 1 Estimation of the current global burden of cryptococcal meningitis among persons living with HIV/AIDS, AIDS, vol.23, pp.525-530, 2009. ,
Cryptococcus neoformans, pp.407-456, 1998. ,
DOI : 10.1128/9781555818241
Determinants of Disease Presentation and Outcome during Cryptococcosis: The CryptoA/D Study, PLoS Medicine, vol.21, issue.2, p.21, 2007. ,
DOI : 10.1371/journal.pmed.0040021.sd002
Sexual reproduction of Cryptococcus Cryptococcus: from human pathogen to model yeast, pp.81-96, 2010. ,
Species Complex, Annual Review of Microbiology, vol.60, issue.1, pp.69-105, 2006. ,
DOI : 10.1146/annurev.micro.60.080805.142102
Mixed Infections and In Vivo Evolution in the Human Fungal Pathogen Cryptococcus neoformans, mBio, vol.1, issue.1, pp.91-101, 2010. ,
DOI : 10.1128/mBio.00091-10
Cryptococcus neoformans Is a Facultative Intracellular Pathogen in Murine Pulmonary Infection, Infection and Immunity, vol.68, issue.7, pp.4225-4237, 2000. ,
DOI : 10.1128/IAI.68.7.4225-4237.2000
Evidence of a Role for Monocytes in Dissemination and Brain Invasion by Cryptococcus neoformans, Infection and Immunity, vol.77, issue.1, pp.120-127, 2009. ,
DOI : 10.1128/IAI.01065-08
Infection after Fungemia, The Journal of Infectious Diseases, vol.186, issue.4, pp.522-530, 2002. ,
DOI : 10.1086/341564
Intracellular pathogenic bacteria and fungi ??? a case of convergent evolution?, Nature Reviews Microbiology, vol.62, issue.2, pp.165-171, 2009. ,
DOI : 10.1038/nrmicro2049
Role of Phagocytosis in the Virulence of Cryptococcus neoformans, Eukaryotic Cell, vol.3, issue.5, pp.1067-1075, 2004. ,
DOI : 10.1128/EC.3.5.1067-1075.2004
Role of Extracellular Phospholipases and Mononuclear Phagocytes in Dissemination of Cryptococcosis in a Murine Model, Infection and Immunity, vol.72, issue.4, pp.2229-2239, 2004. ,
DOI : 10.1128/IAI.72.4.2229-2239.2004
The fatal fungal outbreak on Vancouver Island is characterized by enhanced intracellular parasitism driven by mitochondrial regulation, Proceedings of the National Academy of Sciences, vol.106, issue.31, pp.12980-12985, 2009. ,
DOI : 10.1073/pnas.0902963106
The Outcome of Phagocytic Cell Division with Infectious Cargo Depends on Single Phagosome Formation, PLoS ONE, vol.33, issue.5, p.3219, 2008. ,
DOI : 10.1371/journal.pone.0003219.s009
Extracellular phospholipase activity is a virulence factor for Cryptococcus neoformans, Molecular Microbiology, vol.153, issue.1, pp.166-175, 2001. ,
DOI : 10.1111/j.1574-6968.1994.tb07257.x
Urease as a Virulence Factor in Experimental Cryptococcosis, Infection and Immunity, vol.68, issue.2, pp.443-448, 2000. ,
DOI : 10.1128/IAI.68.2.443-448.2000
Laccase and melanin in the pathogenesis of Cryptococcus neoformans, Frontiers in Bioscience, vol.2, issue.5, pp.99-107, 1997. ,
DOI : 10.2741/A231
The DEAD-box RNA helicase Vad1 regulates multiple virulence-associated genes in Cryptococcus neoformans, Journal of Clinical Investigation, vol.115, issue.3, pp.632-641, 2005. ,
DOI : 10.1172/JCI23048DS1
Roles for inositol-phosphoryl ceramide synthase 1 (IPC1) in pathogenesis of C. neoformans, Genes & Development, vol.15, issue.2, pp.201-212, 2001. ,
DOI : 10.1101/gad.856001
Identification of App1 as a regulator of phagocytosis and virulence of Cryptococcus neoformans, Journal of Clinical Investigation, vol.112, issue.7, pp.1080-1094, 2003. ,
DOI : 10.1172/JCI18309
Regulation of cytochrome c oxidase subunit 1 (COX1) expression in Cryptococcus neoformans by temperature and host environment, Microbiology, vol.149, issue.4, pp.1041-1049, 2003. ,
DOI : 10.1099/mic.0.26021-0
Cryptococcus neoformans interactions with amoebae suggest an explanation for its virulence and intracellular pathogenic strategy in macrophages, Proc. Natl. Acad, 2001. ,
DOI : 10.1073/pnas.261418798
Phagocytosis of Cryptococcus neoformans by, and Nonlytic Exocytosis from, Acanthamoeba castellanii, Applied and Environmental Microbiology, vol.76, issue.18, pp.6056-6062, 2010. ,
DOI : 10.1128/AEM.00812-10
Phenotypic switching of Cryptococcus neoformans occurs in vivo and influences the outcome of infection, Journal of Clinical Investigation, vol.108, issue.11, pp.1639-1648, 2001. ,
DOI : 10.1172/JCI13407
Cytology and ultrastructure of yeasts and yeastlike fungi The yeasts, a taxonomic study, pp.33-44, 1998. ,
Wall structure and bud formation inCryptococcus neoformans, Archives of Microbiology, vol.7, issue.1, pp.205-212, 1974. ,
DOI : 10.1007/BF02451762
Comparison of chitin localization in Saccharomyces cerevisiae, Cryptococcus neoformans, and Malassezia spp., Mycological Research, vol.93, issue.4, pp.551-553, 1989. ,
DOI : 10.1016/S0953-7562(89)80053-X
The cell wall of CryptococcusCryptococcus: from human pathogen to model yeast, pp.67-80, 2010. ,
Determination of lymphocyte division by flow cytometry, Journal of Immunological Methods, vol.171, issue.1, pp.131-137, 1994. ,
DOI : 10.1016/0022-1759(94)90236-4
Strain variation in phagocytosis of Cryptococcus neoformans: dissociation of susceptibility to phagocytosis from activation and binding of opsonic fragments of C3, Infect. Immun, vol.56, pp.2794-2800, 1988. ,
dense granule protein, The Journal of Experimental Medicine, vol.132, issue.1, pp.195-212, 2011. ,
DOI : 10.1084/jem.20091703
Heterogeneity of Wild Leishmania major Isolates in Experimental Murine Pathogenicity and Specific Immune Response, Infection and Immunity, vol.69, issue.8, pp.4906-4915, 2001. ,
DOI : 10.1128/IAI.69.8.4906-4915.2001
Virulence and pathogenicity patterns of Trypanosoma brucei gambiense field isolates in experimentally infected mouse: differences in host immune response modulation by secretome and proteomics, Microbes and Infection, vol.10, issue.1, pp.79-86, 2008. ,
DOI : 10.1016/j.micinf.2007.10.008
Invasion Profiles of Brazilian Field Isolates of Plasmodium falciparum: Phenotypic and Genotypic Analyses, Infection and Immunity, vol.72, issue.10, pp.5886-5891, 2004. ,
DOI : 10.1128/IAI.72.10.5886-5891.2004
Property Differences among the Four Major Candida albicans Strain Clades, Eukaryotic Cell, vol.8, issue.3, pp.373-387, 2009. ,
DOI : 10.1128/EC.00387-08
Cryptococcus neoformans: latency and diseaseCryptococcus: from human pathogen to model yeast, pp.429-430, 2010. ,
Real-time imaging of trapping and urease-dependent transmigration of Cryptococcus neoformans in mouse brain, Journal of Clinical Investigation, vol.120, issue.5, pp.1683-1693, 2010. ,
DOI : 10.1172/JCI41963DS1
Cryptococci at the brain gate: break and enter or use a Trojan horse?, Journal of Clinical Investigation, vol.120, issue.5, pp.1389-1392, 2010. ,
DOI : 10.1172/JCI42949
Dependence of Macrophage Phagocytic Efficacy on Antibody Concentration, Infection and Immunity, vol.75, issue.4, pp.1904-1915, 2007. ,
DOI : 10.1128/IAI.01258-06
Innate Recognition of Fungal Cell Walls, PLoS Pathogens, vol.2, issue.4, p.1000758, 2010. ,
DOI : 10.1371/journal.ppat.1000758.t001
A Major Role for Capsule-Independent Phagocytosis-Inhibitory Mechanisms in Mammalian Infection by Cryptococcus neoformans, Cell Host & Microbe, vol.9, issue.3, pp.243-251, 2011. ,
DOI : 10.1016/j.chom.2011.02.003
???Ready made??? virulence and ???dual use??? virulence factors in pathogenic environmental fungi ??? the Cryptococcus neoformans paradigm, Current Opinion in Microbiology, vol.6, issue.4, pp.332-337, 2003. ,
DOI : 10.1016/S1369-5274(03)00082-1
during early murine pulmonary infection, Molecular Microbiology, vol.5, issue.6, pp.1456-1475, 2008. ,
DOI : 10.1111/j.1365-2958.2008.06374.x
Role of a VPS41 homologue in starvation response, intracellular survival and virulence of Cryptococcus neoformans, Molecular Microbiology, vol.18, issue.5, pp.1132-1146, 2006. ,
DOI : 10.1046/j.1365-2958.2003.03340.x
PI3K signaling of autophagy is required for starvation tolerance and virulenceof Cryptococcus neoformans, Journal of Clinical Investigation, vol.118, issue.3, pp.1186-1197, 2008. ,
DOI : 10.1172/JCI32053
App1: An Antiphagocytic Protein That Binds to Complement Receptors 3 and 2, The Journal of Immunology, vol.182, issue.1, pp.84-91, 2009. ,
DOI : 10.4049/jimmunol.182.1.84
Production , characterization, and antibody specificity of a mouse monoclonal antibody reactive with Cryptococcus neoformans capsular polysaccharide, Infect. Immun, vol.55, pp.742-748, 1987. ,
Cryptococcus neoformans Gene Expression during Murine Macrophage Infection, Eukaryotic Cell, vol.4, issue.8, pp.1420-1433, 2005. ,
DOI : 10.1128/EC.4.8.1420-1433.2005
The Human Fungal Pathogen Cryptococcus Can Complete Its Sexual Cycle during a Pathogenic Association with Plants, Cell Host & Microbe, vol.1, issue.4, pp.263-273, 2007. ,
DOI : 10.1016/j.chom.2007.05.005
Role of an Expanded Inositol Transporter Repertoire in Cryptococcus neoformans Sexual Reproduction and Virulence, mBio, vol.1, issue.1, pp.84-94, 2010. ,
DOI : 10.1128/mBio.00084-10
A new mathematical model for relative quantification in real-time RT-PCR, Nucleic Acids Research, vol.29, issue.9, p.45, 2001. ,
DOI : 10.1093/nar/29.9.e45
qBase relative quantification framework and software for management and automated analysis of real-time quantitative PCR data, Genome Biology, vol.8, issue.2, p.19, 2007. ,
DOI : 10.1186/gb-2007-8-2-r19
TM4: a free, open-source system for microarray data management and analysis, Biotechniques, vol.34, pp.374-378, 2003. ,