Two-component spike nanoparticle vaccine protects macaques from SARS-CoV-2 infection

Philip J.M. Brouwer (1) , Mitch Brinkkemper (1) , Pauline Maisonnasse (2) , Nathalie Dereuddre-Bosquet (2) , Marloes Grobben (1) , Mathieu Claireaux (1) , Marlon de Gast (1) , Romain Marlin (2) , Virginie Chesnais (3) , Ségolène Diry (3) , Joel Allen (4) , Yasunori Watanabe (4, 5) , Julia Giezen (1) , Gius Kerster , Hannah Turner (6) , Karlijn van der Straten , Cynthia van der Linden , Yoann Aldon (7) , Thibaut Naninck (2) , Ilja Bontjer (8) , Judith Burger , Meliawati Poniman , Anna Mykytyn (9) , Nisreen M.A. Okba (9) , Edith Schermer , Marielle van Breemen , Rashmi Ravichandran (10) , Tom Caniels , Jelle van Schooten , Nidhal Kahlaoui (2) , Vanessa Contreras (2) , Julien Lemaître (2) , Catherine Chapon (2) , Raphaël Ho Tsong Fang (2) , Julien Villaudy (11) , Kwinten Sliepen , Yme van der Velden , Bart Haagmans , Godelieve de Bree , Eric Ginoux , Andrew Ward (6) , Max Crispin , Neil King , Sylvie van der Werf (12, 13) , Marit van Gils (1) , Roger Le Grand (2) , Rogier Sanders (1)

1 Department of Medical Microbiology and Infection Prevention [Amsterdam]
2 IMVA-HB - Immunologie des maladies virales, auto-immunes, hématologiques et bactériennes
3 Life and Soft
4 University of Southampton
5 University of Oxford
6 The Scripps Research Institute [La Jolla, San Diego]
7 Imperial College London
8 Amsterdam UMC - Amsterdam University Medical Center
9 Erasmus MC - Erasmus University Medical Center [Rotterdam]
10 University of Washington [Seattle]
11 AIMM Therapeutics [Amsterdam, the Netherlands]
12 GMV-ARN (UMR_3569 / U-Pasteur_2) - Génétique Moléculaire des Virus à ARN - Molecular Genetics of RNA Viruses
13 CNR - laboratoire coordonnateur - Centre National de Référence des virus des infections respiratoires (dont la grippe) - National Reference Center Virus Influenzae [Paris]

Domains: Life Sciences [q-bio]

Philip J.M. Brouwer, Mitch Brinkkemper, Pauline Maisonnasse, Nathalie Dereuddre-Bosquet, Marloes Grobben, et al.. Two-component spike nanoparticle vaccine protects macaques from SARS-CoV-2 infection. Cell, 2021, 184 (5), pp.1188-1200.e19. ⟨10.1016/j.cell.2021.01.035⟩. ⟨pasteur-04098199⟩