Actin subversion for productive Plasmodium hepatocyte invasion [Spotlight]

Freddy Frischknecht (1) , Jost Enninga (2)

1 University of Heidelberg, Medical Faculty
2 Dynamique des Interactions Hôte-Pathogène - Dynamics of Host-Pathogen Interactions

Productive invasion of hepatocytes by Plasmodium sporozoites is a key step of infection. The parasites traverse hepatocytes before targeting one of them to form a parasitophorous vacuole for parasite expansion. Schepis et al. show the induction of membrane ruffling via host Rho GTPases by Plasmodium sporozoites facilitating productive invasion.

Mots clés: Plasmodium; actin rearrangements; bacterial pathogens; host cell invasion.

Domaines: Sciences du Vivant [q-bio]

Freddy Frischknecht, Jost Enninga. Actin subversion for productive Plasmodium hepatocyte invasion [Spotlight]. Trends in Parasitology, In press, ⟨10.1016/j.pt.2023.03.003⟩. ⟨pasteur-04059699⟩