Reconstructing Mayotte 2018–19 Rift Valley Fever outbreak in humans by combining serological and surveillance data - Archive ouverte HAL Access content directly
Journal Articles Communications Medicine Year : 2022

Reconstructing Mayotte 2018–19 Rift Valley Fever outbreak in humans by combining serological and surveillance data

(1) , (2, 3) , (1) , (1) , (4) , (1, 5) , (5) , (1) , (2, 3) , (6) , (1)
1
2
3
4
5
6

Abstract

Background: Rift Valley Fever (RVF) is a zoonosis that affects large parts of Africa and the Arabian Peninsula. RVF virus (RVFV) is transmitted to humans through contacts with infected animals, animal products, mosquito bites or aerosols. Its pathogenesis in humans ranges from asymptomatic forms to potentially deadly haemorrhagic fevers, and the true burden of human infections during outbreaks is generally unknown. Methods: We build a model fitted to both passive surveillance data and serological data collected throughout a RVF epidemic that occurred in Mayotte Island in 2018–2019. Results: We estimate that RVFV infected 10,797 (95% CrI 4,728–16,127) people aged ≥15 years old in Mayotte during the entire outbreak, among which only 1.2% (0.67%–2.2%) were reported to the syndromic surveillance system. RVFV IgG seroprevalence in people ≥15 years old was estimated to increase from 5.5% (3.6%–7.7%) before the outbreak to 12.9% (10.4%–16.3%) thereafter. Conclusions: Our results suggest that a large part of RVFV infected people present subclinical forms of the disease and/or do not reach medical care that could lead to their detection by the surveillance system. This may threaten the implementation of exhaustive RVF surveillance and adequate control programs in affected countries.
Fichier principal
Vignette du fichier
Bastard_CommunicationsMedicine2022.pdf (716.76 Ko) Télécharger le fichier
Origin : Publication funded by an institution
Licence : CC BY - Attribution

Dates and versions

pasteur-03926740 , version 1 (06-01-2023)

Licence

Attribution - CC BY 4.0

Identifiers

Cite

Jonathan Bastard, Guillaume André Durand, Fanny Parenton, Youssouf Hassani, Laure Dommergues, et al.. Reconstructing Mayotte 2018–19 Rift Valley Fever outbreak in humans by combining serological and surveillance data. Communications Medicine, 2022, 2, pp.163. ⟨10.1038/s43856-022-00230-4⟩. ⟨pasteur-03926740⟩
0 View
0 Download

Altmetric

Share

Gmail Facebook Twitter LinkedIn More