Cross-host evolution of severe acute respiratory syndrome coronavirus in palm civet and human - Archive ouverte HAL Access content directly
Journal Articles Proceedings of the National Academy of Sciences of the United States of America Year : 2005

Cross-host evolution of severe acute respiratory syndrome coronavirus in palm civet and human

(1) , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , (2) , (2) , (2) , , , ,
1
2
Chang-Chun Tu
  • Function : Author
Guo-Wei Zhang
  • Function : Author
Sheng-Yue Wang
  • Function : Author
Kui Zheng
  • Function : Author
Lian-Cheng Lei
  • Function : Author
Qiu-Xia Chen
  • Function : Author
Yu-Wei Gao
  • Function : Author
Hui-Qiong Zhou
  • Function : Author
Hua Xiang
  • Function : Author
Hua-Jun Zheng
  • Function : Author
Shur-Wern Wang Chern
  • Function : Author
Feng Cheng
  • Function : Author
Chun-Ming Pan
  • Function : Author
Hua Xuan
  • Function : Author
Sai-Juan Chen
  • Function : Author
Hui-Ming Luo
  • Function : Author
Duan-Hua Zhou
  • Function : Author
Yu-Fei Liu
  • Function : Author
Jian-Feng He
  • Function : Author
Peng-Zhe Qin
  • Function : Author
Ling-Hui Li
  • Function : Author
Yu-Qi Ren
  • Function : Author
Wen-Jia Liang
  • Function : Author
Ye-Dong Yu
  • Function : Author
Larry Anderson
  • Function : Author
Ming Wang
  • Function : Author
Rui-Heng Xu
  • Function : Author
Xin-Wei Wu
  • Function : Author
Huan-Ying Zheng
  • Function : Author
Jin-Ding Chen
  • Function : Author
Guodong Liang
  • Function : Author
Yang Gao
  • Function : Author
Ming Liao
  • Function : Author
Ling Fang
  • Function : Author
Li-Yun Jiang
  • Function : Author
Hui Li
  • Function : Author
Fang Chen
  • Function : Author
Biao Di
  • Function : Author
Li-Juan He
  • Function : Author
Jin-Yan Lin
  • Function : Author
Suxiang Tong
  • Function : Author
Xiangang Kong
  • Function : Author
Lin Du
  • Function : Author
Pei Hao
  • Function : Author
Hua Tang
  • Function : Author
Andrea Bernini
  • Function : Author
Xiao-Jing Yu
  • Function : Author
Ottavia Spiga
  • Function : Author
Zong-Ming Guo
  • Function : Author
Hai-Yan Pan
  • Function : Author
Wei-Zhong He
  • Function : Author
Neri Niccolai
  • Function : Author
Yi-Xue Li
  • Function : Author
Chung-I Wu
  • Function : Author
Guo-Ping Zhao
  • Function : Author

Abstract

The genomic sequences of severe acute respiratory syndrome coronaviruses from human and palm civet of the 2003/2004 outbreak in the city of Guangzhou, China, were nearly identical. Phylogenetic analysis suggested an independent viral invasion from animal to human in this new episode. Combining all existing data but excluding singletons, we identified 202 single-nucleotide variations. Among them, 17 are polymorphic in palm civets only. The ratio of nonsynonymous/synonymous nucleotide substitution in palm civets collected 1 yr apart from different geographic locations is very high, suggesting a rapid evolving process of viral proteins in civet as well, much like their adaptation in the human host in the early 2002–2003 epidemic. Major genetic variations in some critical genes, particularly the Spike gene, seemed essential for the transition from animal-to-human transmission to human-to-human transmission, which eventually caused the first severe acute respiratory syndrome outbreak of 2002/2003.

Dates and versions

pasteur-03915126 , version 1 (29-12-2022)

Identifiers

Cite

Huai-Dong Song, Chang-Chun Tu, Guo-Wei Zhang, Sheng-Yue Wang, Kui Zheng, et al.. Cross-host evolution of severe acute respiratory syndrome coronavirus in palm civet and human. Proceedings of the National Academy of Sciences of the United States of America, 2005, 102 (7), pp.2430-2435. ⟨10.1073/pnas.0409608102⟩. ⟨pasteur-03915126⟩

Collections

PASTEUR
0 View
0 Download

Altmetric

Share

Gmail Facebook Twitter LinkedIn More