Heat inactivation of the severe acute respiratory syndrome coronavirus 2

Christophe Batéjat (1) , Quentin Grassin (1) , Jean-Claude Manuguerra (1) , India Leclercq (1, 2)

1 CIBU - Cellule d'Intervention Biologique d'Urgence (Centre National de Référence) - Laboratory for Urgent Response to Biological Threats (National Reference Center)
2 Cellule Pasteur

Cell culture medium, nasopharyngeal and sera samples spiked with SARS-CoV-2 were subjected to heat inactivation for various periods of time, ranging from 30 s to 60 min. Our results showed that SARS-CoV-2 could be inactivated in less than 30 min, 15 min, and 3 min at 56 °C, 65 °C, and 95 °C, respectively. These data could help laboratory workers to improve their protocols by handling the virus in biosafety conditions.

Mots clés: Heat; Inactivation; SARS-CoV-2; Covid-19

Domaines: Sciences du Vivant [q-bio]

Christophe Batéjat, Quentin Grassin, Jean-Claude Manuguerra, India Leclercq. Heat inactivation of the severe acute respiratory syndrome coronavirus 2. Journal of Biosafety and Biosecurity, 2021, 3 (1), pp.1-3. ⟨10.1016/j.jobb.2020.12.001⟩. ⟨pasteur-03915049⟩