Heat inactivation of monkeypox virus

Christophe Batéjat (1, 1) , Quentin Grassin (1, 1) , Maxence Feher (1, 1) , Damien Hoinard (1, 1) , Jessica Vanhomwegen (1, 1) , Jean-Claude Manuguerra (1, 1) , India Leclercq (1, 1)

1 CIBU - Cellule d'Intervention Biologique d'Urgence (Centre National de Référence) - Laboratory for Urgent Response to Biological Threats (National Reference Center)

Different kinds of media spiked with monkeypox virus (MPXV) were subjected to heat inactivation at different temperatures for various periods of time. The results showed that MPXV was inactivated in less than 5 min at 70 °C and less than 15 min at 60 °C, with no difference between viruses from the West African and Central African clades. The present findings could help laboratory workers to manipulate MPXV in optimal biosafety conditions and improve their protocols.

Keywords: Heat; Inactivation; Monkeypoxvirus; Virus

Domains: Life Sciences [q-bio]

Christophe Batéjat, Quentin Grassin, Maxence Feher, Damien Hoinard, Jessica Vanhomwegen, et al.. Heat inactivation of monkeypox virus. Journal of Biosafety and Biosecurity, 2022, 4 (2), pp.121-123. ⟨10.1016/j.jobb.2022.08.001⟩. ⟨pasteur-03915042⟩