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The immune factors driving DNA methylation variation in human blood

Abstract : Epigenetic changes are required for normal development, yet the nature and respective contribution of factors that drive epigenetic variation in humans remain to be fully characterized. Here, we assessed how the blood DNA methylome of 884 adults is affected by DNA sequence variation, age, sex and 139 factors relating to life habits and immunity. Furthermore, we investigated whether these effects are mediated or not by changes in cellular composition, measured by deep immunophenotyping. We show that DNA methylation differs substantially between naïve and memory T cells, supporting the need for adjustment on these cell-types. By doing so, we find that latent cytomegalovirus infection drives DNA methylation variation and provide further support that the increased dispersion of DNA methylation with aging is due to epigenetic drift. Finally, our results indicate that cellular composition and DNA sequence variation are the strongest predictors of DNA methylation, highlighting critical factors for medical epigenomics studies.
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Contributor : Marie-Christine Vougny Connect in order to contact the contributor
Submitted on : Tuesday, November 22, 2022 - 10:16:47 AM
Last modification on : Friday, November 25, 2022 - 11:12:37 AM


Distributed under a Creative Commons Attribution 4.0 International License





Jacob Bergstedt, Sadoune Ait Kaci Azzou, Kristin Tsuo, Anthony Jaquaniello, Alejandra Urrutia, et al.. The immune factors driving DNA methylation variation in human blood. Nature Communications, 2022, 13 (1), pp.5895. ⟨10.1038/s41467-022-33511-6⟩. ⟨pasteur-03865045⟩



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