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Imprinted antibody responses against SARS-CoV-2 Omicron sublineages

Young-Jun Park 1 Dora Pinto 2 Alexandra C. Walls 1 Zhuoming Liu 3 Anna de Marco 2 Fabio Benigni 2 Fabrizia Zatta 2 Chiara Silacci-Fregni 2 Jessica Bassi 2 Kaitlin R. Sprouse 1 Amin Addetia 1 John E. Bowen 1 Cameron Stewart 1 Martina Giurdanella 2 Christian Saliba 2 Barbara Guarino 2 Michael A. Schmid 2 Nicholas M. Franko 1 Jennifer K. Logue 1 Ha V. Dang 4 Kevin Hauser 4 Julia Di Iulio 4 William Rivera 4 Gretja Schnell 4 Anushka Rajesh 4 Jiayi Zhou 4 Nisar Farhat 4 Hannah Kaiser 4 Martin Montiel-Ruiz 4 Julia Noack 4 Florian A. Lempp 4 Javier Janer 3 Rana Abdelnabi 5 Piet Maes 5 Paolo Ferrari 6, 7, 8 Alessandro Ceschi 6, 7, 9 Olivier Giannini 6, 10 Guilherme Dias de Melo 11 Lauriane Kergoat 11 Hervé Bourhy 11 Johan Neyts 5 Leah Soriaga 4 Lisa A. Purcell 4 Gyorgy Snell 4 Sean P.J. Whelan 3 Antonio Lanzavecchia 2 Herbert W. Virgin 4, 3, 12 Luca Piccoli 2 Helen Y. Chu 1 Matteo Samuele Pizzuto 2 Davide Corti 2, * David Veesler 1, * 
Abstract : Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) Omicron sublineages carry distinct spike mutations and represent an antigenic shift resulting in escape from antibodies induced by previous infection or vaccination. We show that hybrid immunity or vaccine boosters elicit plasma neutralizing activity against Omicron BA.1, BA.2, BA.2.12.1 and BA.4/5 and that breakthrough infections, but not vaccination-only, induce neutralizing activity in the nasal mucosa. Consistent with immunological imprinting, most antibodies derived from memory B cells or plasma cells of Omicron breakthrough cases cross-react with the Wuhan-Hu-1, BA.1, BA.2, and BA.4/5 receptor-binding domains whereas Omicron primary infections elicit B cells of narrow specificity up to 6 months post infection. Although most clinical antibodies have reduced neutralization of Omicron, we identified an ultrapotent pan-variant neutralizing antibody, that is a strong candidate for clinical development.
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Contributor : Guilherme Dias de Melo Connect in order to contact the contributor
Submitted on : Monday, October 24, 2022 - 6:26:14 PM
Last modification on : Wednesday, November 2, 2022 - 2:11:30 PM


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Distributed under a Creative Commons Attribution 4.0 International License




Young-Jun Park, Dora Pinto, Alexandra C. Walls, Zhuoming Liu, Anna de Marco, et al.. Imprinted antibody responses against SARS-CoV-2 Omicron sublineages. Science, 2022, pp.First release. ⟨10.1126/science.adc9127⟩. ⟨pasteur-03827707⟩



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