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Global spatial dynamics and vaccine-induced fitness changes of Bordetella pertussis

Noémie Lefrancq 1, 2 Valérie Bouchez 3, 4 Nadia Fernandes 3 Alex-Mikael Barkoff 5 Thijs Bosch 6 Tine Dalby 7 Thomas Åkerlund 8 Jessica Darenberg 8 Katerina Fabianova 9 Didrik Vestrheim 10 Norman Fry 11 Juan José González-López 12, 13 Karolina Gullsby 14 Adele Habington 15 Qiushui He 5 David Litt 11 Helena Martini 16 Denis Piérard 16 Paola Stefanelli 17 Marc Stegger 7 Jana Zavadilova 9 Nathalie Armatys 3, 4 Annie Landier 3, 4 Sophie Guillot 3, 4 Samuel Hong 18 Philippe Lemey 18 Julian Parkhill 2 Julie Toubiana 3, 4, 19 Simon Cauchemez 1 Henrik Salje 1, 2, * Sylvain Brisse 3, 4, * 
Abstract : As with other pathogens, competitive interactions between Bordetella pertussis strains drive infection risk. Vaccines are thought to perturb strain diversity through shifts in immune pressures; however, this has rarely been measured because of inadequate data and analytical tools. We used 3344 sequences from 23 countries to show that, on average, there are 28.1 transmission chains circulating within a subnational region, with the number of chains strongly associated with host population size. It took 5 to 10 years for B. pertussis to be homogeneously distributed throughout Europe, with the same time frame required for the United States. Increased fitness of pertactin-deficient strains after implementation of acellular vaccines, but reduced fitness otherwise, can explain long-term genotype dynamics. These findings highlight the role of vaccine policy in shifting local diversity of a pathogen that is responsible for 160,000 deaths annually.
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https://hal-pasteur.archives-ouvertes.fr/pasteur-03821663
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Submitted on : Wednesday, October 19, 2022 - 6:04:17 PM
Last modification on : Friday, October 21, 2022 - 3:57:44 AM

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Noémie Lefrancq, Valérie Bouchez, Nadia Fernandes, Alex-Mikael Barkoff, Thijs Bosch, et al.. Global spatial dynamics and vaccine-induced fitness changes of Bordetella pertussis. Science Translational Medicine, 2022, 14 (642), pp.eabn3253. ⟨10.1126/scitranslmed.abn3253⟩. ⟨pasteur-03821663⟩

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