Bidirectional Interactions between Arboviruses and the Bacterial and Viral Microbiota in Aedes aegypti and Culex quinquefasciatus

Chenyan Shi (1, 2) , Leen Beller (2) , Lanjiao Wang (2) , Ana Rosales Rosas (2) , Lander de Coninck (2) , Lyza Héry (3) , Laurence Mousson (4) , Nonito Pagès (5, 6) , Jeroen Raes (7) , Leen Delang (2) , Anubis Vega-Rúa (3) , Anna-Bella Failloux (4) , Jelle Matthijnssens (2)

1 Shenzhen University [Shenzhen]
2 Rega Institute for Medical Research [Leuven, België]
3 Institut Pasteur de la Guadeloupe
4 Arbovirus et Insectes Vecteurs - Arboviruses and Insect Vectors
5 UMR ASTRE - Animal, Santé, Territoires, Risques et Ecosystèmes
6 Cirad-BIOS - Département Systèmes Biologiques
7 VIB-KU Leuven Center for Microbiology [Leuven, Belgium]

In this study, we first utilized the single mosquito microbiome analysis, demonstrating a complex three-way interaction among arboviruses, resident microbiota, and the host, which is distinct for different arbovirus–mosquito combinations. Some of the previously described “core virus” increased in the mosquitos receiving viral blood meal, like Guadeloupe mosquito virus and Guadeloupe Culex tymo-like virus, suggesting their potential roles in ZIKV and WNV infection.

Mots clés: arbovirus; microbiome; mosquito-arbovirus-microbiota interaction; phageome; single mosquito metagenomics; virome

Domaines: Sciences du Vivant [q-bio]

Chenyan Shi, Leen Beller, Lanjiao Wang, Ana Rosales Rosas, Lander de Coninck, et al.. Bidirectional Interactions between Arboviruses and the Bacterial and Viral Microbiota in Aedes aegypti and Culex quinquefasciatus. mBio, 2022, 13 (5), pp.e0102122. ⟨10.1128/mbio.01021-22⟩. ⟨pasteur-03781167⟩