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Journal Articles Nature Communications Year : 2022

A phylogenetically-restricted essential cell cycle progression factor in the human pathogen Candida albicans

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Abstract

Abstract Chromosomal instability caused by cell division errors is associated with antifungal drug resistance in fungal pathogens. Here, we identify potential mechanisms underlying such instability by conducting an overexpression screen monitoring chromosomal stability in the human fungal pathogen Candida albicans . Analysis of ~1000 genes uncovers six c hromosomal s t a bility ( CSA ) genes, five of which are related to cell division genes of other organisms. The sixth gene, CSA6 , appears to be present only in species belonging to the CUG-Ser clade, which includes C. albicans and other human fungal pathogens. The protein encoded by CSA6 localizes to the spindle pole bodies, is required for exit from mitosis, and induces a checkpoint-dependent metaphase arrest upon overexpression. Thus, Csa6 is an essential cell cycle progression factor that is restricted to the CUG-Ser fungal clade, and could therefore be explored as a potential antifungal target.
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Dates and versions

pasteur-03760524 , version 1 (25-08-2022)

Licence

Attribution - CC BY 4.0

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Priya Jaitly, Mélanie Legrand, Abhijit Das, Tejas Patel, Murielle Chauvel, et al.. A phylogenetically-restricted essential cell cycle progression factor in the human pathogen Candida albicans. Nature Communications, 2022, 13 (1), pp.4256. ⟨10.1038/s41467-022-31980-3⟩. ⟨pasteur-03760524⟩
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