Uncontrolled donation after circulatory death: comparison of two kidney preservation protocols on graft outcomes - Archive ouverte HAL Access content directly
Journal Articles BMC Nephrology Year : 2018

Uncontrolled donation after circulatory death: comparison of two kidney preservation protocols on graft outcomes

(1, 2, 3) , (1, 2) , (1) , (4) , (1) , (5) , (1, 2) , (1, 2) , (1) , (1) , (1) , (1, 2) , (6) , (1, 2) , (1) , (7) , (1, 2, 3)
1
2
3
4
5
6
7

Abstract

Background Kidney transplantation following uncontrolled donation after circulatory death (uDCD) presents a high risk of delayed graft function due to prolonged warm ischemia time. In order to minimise the effects of ischemia/reperfusion injury during warm ischemia, normothermic recirculation recently replaced in situ perfusion prior to implantation in several institutions. The aim of this study was to compare these preservation methods on kidney graft outcomes. Methods The primary endpoint was the one-year measured graft filtration rate (mGFR). We collected retrospective data from 64 consecutive uDCD recipients transplanted over a seven-year period in a single centre. Results Thirty-two grafts were preserved by in situ perfusion and 32 by normothermic recirculation. The mean ± SD mGFR at 1 year post-transplantation was 43.0 ± 12.8 mL/min/1.73 m2 in the in situ perfusion group and 53.2 ± 12.8 mL/min/1.73 m2 in the normothermic recirculation group (p = 0.01). Estimated GFR levels were significantly higher in the normothermic recirculation group at 12 months (p = 0.01) and 24 months (p = 0.03) of follow-up. We did not find any difference between groups regarding patient and graft survival, delayed graft function, graft rejection, or interstitial fibrosis. Conclusions Function of grafts preserved by normothermic recirculation was better at 1 year and the results suggest that this persists at 2 years, although no difference was found in short-term outcomes. Despite the retrospective design, this study provides an additional argument in favour of normothermic recirculation.
Fichier principal
Vignette du fichier
s12882-017-0805-1.pdf (558.63 Ko) Télécharger le fichier
Origin : Publication funded by an institution

Dates and versions

pasteur-03721333 , version 1 (12-07-2022)

Licence

Attribution - CC BY 4.0

Identifiers

Cite

Claire Delsuc, Alexandre Faure, Julien Berthiller, Didier Dorez, Xavier Matillon, et al.. Uncontrolled donation after circulatory death: comparison of two kidney preservation protocols on graft outcomes. BMC Nephrology, 2018, 19 (1), pp.3. ⟨10.1186/s12882-017-0805-1⟩. ⟨pasteur-03721333⟩
10 View
15 Download

Altmetric

Share

Gmail Facebook Twitter LinkedIn More