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A highly virulent variant of HIV-1 circulating in the Netherlands

Wymant Chris 1 Bezemer Daniela 2 Blanquart François 3 Ferretti Luca 1 Gall Astrid 4 Hall Matthew 1 Golubchik Tanya 1 Bakker Margreet 5 Ong Swee Hoe 6 Zhao Lele 1 Bonsall David 1 Cesare Mariateresa De 1 Macintyre-Cockett George 1 Abeler-Dörner Lucie 1 Albert Jan 7 Bannert Norbert 8 Fellay Jacques 9 Grabowski M Kate 10 Gunsenheimer-Bartmeyer Barbara 8 Günthard Huldrych F 11 Kivelä Pia 12 Kouyos Roger D 11 Laeyendecker Oliver 13 Meyer Laurence 14 Porter Kholoud 15 Ristola Matti 12 Sighem Ard Van 2 Berkhout Ben 5 Kellam Paul 16 Cornelissen Marion 5 Reiss Peter 5 Fraser Christophe 1 Netherlands Athena Hiv Observational Cohort Beehive Collaboration Asier Sáez-Cirión 17 
Abstract : We discovered a highly virulent variant of subtype-B HIV-1 in the Netherlands. One hundred nine individuals with this variant had a 0.54 to 0.74 log 10 increase (i.e., a ~3.5-fold to 5.5-fold increase) in viral load compared with, and exhibited CD4 cell decline twice as fast as, 6604 individuals with other subtype-B strains. Without treatment, advanced HIV—CD4 cell counts below 350 cells per cubic millimeter, with long-term clinical consequences—is expected to be reached, on average, 9 months after diagnosis for individuals in their thirties with this variant. Age, sex, suspected mode of transmission, and place of birth for the aforementioned 109 individuals were typical for HIV-positive people in the Netherlands, which suggests that the increased virulence is attributable to the viral strain. Genetic sequence analysis suggests that this variant arose in the 1990s from de novo mutation, not recombination, with increased transmissibility and an unfamiliar molecular mechanism of virulence.
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Submitted on : Tuesday, June 21, 2022 - 1:56:12 PM
Last modification on : Tuesday, August 2, 2022 - 3:21:24 AM



Wymant Chris, Bezemer Daniela, Blanquart François, Ferretti Luca, Gall Astrid, et al.. A highly virulent variant of HIV-1 circulating in the Netherlands. Science, American Association for the Advancement of Science (AAAS), 2022, 375 (6580), pp.540-545. ⟨10.1126/science.abk1688⟩. ⟨pasteur-03700743⟩



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