Emergence and global spread of Listeria monocytogenes main clinical clonal complex

Alexandra Moura (1, 2) , Noémie Lefrancq (3) , Alexandre Leclercq (1, 2) , Thierry Wirth (4) , Vítor Borges (5) , Brent Gilpin (6) , Timothy J. Dallman (7) , Joachim Frey (8) , Eelco Franz (9) , Eva M. Nielsen (10) , Juno Thomas (11) , Arthur Pightling (12) , Benjamin P. Howden (13, 14) , Cheryl L. Tarr (15) , Peter Gerner-Smidt (15) , Simon Cauchemez (3) , Henrik Salje (3) , Sylvain Brisse (16) , Marc Lecuit (1, 2, 17) , The Listeria Cc1 Study Group

1 Biologie des Infections - Biology of Infection
2 CNRL - Centre National de Référence Listeria - National Reference Center Listeria
3 Modélisation mathématique des maladies infectieuses - Mathematical modelling of Infectious Diseases
4 ISYEB - Institut de Systématique, Evolution, Biodiversité
5 INSA - Instituto Nacional de Saùde Dr Ricardo Jorge [Portugal]
6 ESR - Institute of Environmental Science and Research
7 Public Health England [London]
8 UNIBE - Universität Bern / University of Bern
9 RIVM - National Institute for Public Health and the Environment [Bilthoven]
10 Statens Serum Institut [Copenhagen]
11 NICD - National Institute for Communicable Diseases [Johannesburg]
12 FDA - U.S. Food and Drug Administration
13 The Peter Doherty Institute for Infection and Immunity [Melbourne]
14 Austin Health
15 CDC - Centers for Disease Control and Prevention [Atlanta]
16 Biodiversité et Epidémiologie des Bactéries pathogènes - Biodiversity and Epidemiology of Bacterial Pathogens
17 Service des Maladies infectieuses et tropicales [CHU Necker]

Retracing microbial emergence and spread is essential to understanding the evolution and dynamics of pathogens. The bacterial foodborne pathogen Listeria monocytogenes clonal complex 1 ( Lm -CC1) is the most prevalent clonal group associated with listeriosis, and is strongly associated with cattle and dairy products. Here we analysed 2,021 Lm -CC1 isolates collected from 40 countries, since the first Lm isolation to the present day, to define its evolutionary history and population dynamics. Our results suggest that Lm -CC1 spread worldwide from North America following the Industrial Revolution through two waves of expansion, coinciding with the transatlantic livestock trade in the second half of the 19 th century and the rapid growth of cattle farming in the 20 th century. Lm -CC1 then firmly established at a local level, with limited inter-country spread. This study provides an unprecedented insight into Lm -CC1 phylogeography and dynamics and can contribute to effective disease surveillance to reduce the burden of listeriosis.

Domaines: Bactériologie

Alexandra Moura, Noémie Lefrancq, Alexandre Leclercq, Thierry Wirth, Vítor Borges, et al.. Emergence and global spread of Listeria monocytogenes main clinical clonal complex. 2020. ⟨pasteur-03696138v1⟩