Dynamic Changes of Mitochondrial DNA Copy Number in Gastrointestinal Tract Cancers: A Systematic Review and Meta-Analysis

Mehdi Alikhani (1) , Eliette Touati (2) , Morteza Karimipoor (1) , Massoud Vosough (3) , Sana Eybpoosh (1) , Marjan Mohammadi (1)

1 Institut Pasteur d'Iran
2 Pathogenèse de Helicobacter / Helicobacter Pathogenesis
3 ACECR - Academic Center for Education, Culture and Research

We have performed a systematic review and meta-analysis for evaluation of mitochondrial DNA copy number (mtDNA-CN) alterations in peripheral blood leukocytes (PBL), and tumor tissues of gastrointestinal tract (GIT) cancers. Analysis of the PBL demonstrated a significant decrease [OR: 0.6 (0.5, 0.8)] and increase [OR: 1.4 (1.1, 1.9)] prior to and following GIT cancer development, respectively. This trend was more evident in CRC, and GC subgroups. Analysis of tissue yielded high levels of heterogeneity. However, the mean difference for the CRC subgroup was statistically significant [1.5 (1.0, 2.2)]. Our analysis suggests mtDNA-CN deserves further investigations as a GIT-cancer screening tool.

Keywords: mtDNA copy number; gastrointestinal tract cancers; systematic review; PBL; systematic review and meta-analysis; tumor

Domains: Life Sciences [q-bio]; Cancer

Mehdi Alikhani, Eliette Touati, Morteza Karimipoor, Massoud Vosough, Sana Eybpoosh, et al.. Dynamic Changes of Mitochondrial DNA Copy Number in Gastrointestinal Tract Cancers: A Systematic Review and Meta-Analysis. Cancer Investigation, 2021, 39 (2), pp.1-20. ⟨10.1080/07357907.2020.1857394⟩. ⟨pasteur-03688626⟩