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Organ‐on‐chip to investigate host‐pathogens interactions

Abstract : Infectious diseases remain the subject of intense research. This topic reaches a new era towards the study of host-pathogen interactions mechanisms at the tissue scale. The past few years have hence witnessed the emergence of new methods. Among them, organ-on-chip, which combines biomaterial technology, microfluidic and tissue engineering to recreate the organ physiology is very promising. This review summarises how this technology recapitulates the architecture, the mechanical stimulation and the interface of a tissue and how this particular microenvironment is critical to study host-pathogen interactions.
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Submitted on : Tuesday, May 24, 2022 - 5:33:39 PM
Last modification on : Saturday, June 25, 2022 - 3:44:15 AM

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Thomas Feaugas, Nathalie Sauvonnet. Organ‐on‐chip to investigate host‐pathogens interactions. Cellular Microbiology, Wiley, 2021, 23 (7), pp.e13336. ⟨10.1111/cmi.13336⟩. ⟨pasteur-03677610⟩

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