Linking microbiota composition with antimalarial antibody response

Ottavia Romoli (1) , Liliana Mancio-Silva (2, 3) , Mathilde Gendrin (1, 3)

1 Microbiote des insectes vecteurs / Microbiota of Insect Vectors [Cayenne, Guyane française]
2 Biologie des Interactions Hôte-Parasite - Biology of Host-Parasite Interactions
3 Département Parasites et Insectes vecteurs - Department of Parasites and Insect Vectors

Microbiota composition recently arose as a factor correlating with malaria infection. Mandal et al. showed, via cecal transplant and antibacterial treatment, that the mouse microbiota modulates parasitemia by affecting spleen germinal centers where B cells are matured. They further identified correlations between microbiota composition and malaria severity in Ugandan children.

Keywords: Plasmodium; malaria; microbiota; severity

Domains: Life Sciences [q-bio]; Microbiology and Parasitology

Ottavia Romoli, Liliana Mancio-Silva, Mathilde Gendrin. Linking microbiota composition with antimalarial antibody response. Trends in Parasitology, 2021, 37 (10), pp.853-855. ⟨10.1016/j.pt.2021.07.007⟩. ⟨pasteur-03672692⟩