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APOBEC3C S188I Polymorphism Enhances Context-Specific Editing of Hepatitis B Virus Genome

Abstract : Single-nucleotide polymorphism in APOBEC3C (resulting in a serine to isoleucine in position 188) is present in approximately 10% of African populations and greatly enhances restriction against human immunodeficiency virus-1 and simian immunodeficiency virus by improving dimerization and DNA processivity of the enzyme. In this study, we demonstrated in culture and in infected patients that hepatitis B virus (HBV) could be edited by APOBEC3CS188I. Using next-generation sequencing, we demonstrated that APOBEC3CS188I led to enhanced editing activity in 5ʹTpCpA→5ʹTpTpA context. This constitutes a new hallmark of this enzyme, which could be used to determine its impact on HBV or nuclear DNA.
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https://hal-pasteur.archives-ouvertes.fr/pasteur-03671452
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Submitted on : Wednesday, May 18, 2022 - 1:35:58 PM
Last modification on : Saturday, May 21, 2022 - 3:20:41 AM

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Pierre Khalfi, Rodolphe Suspène, Vincent Caval, Valérie Thiers, Guillaume Beauclair, et al.. APOBEC3C S188I Polymorphism Enhances Context-Specific Editing of Hepatitis B Virus Genome. Journal of Infectious Diseases, Oxford University Press (OUP), 2022, pp.jiac003. ⟨10.1093/infdis/jiac003⟩. ⟨pasteur-03671452⟩

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