Transient viral exposure drives functionally-coordinated humoral immune responses in HIV-1 post-treatment controllers
(1)
,
(1)
,
(2)
,
(3)
,
(3)
,
(4)
,
(4)
,
(5)
,
(3)
,
(6)
,
(2)
,
(1)
,
,
,
,
(7)
,
(7)
,
(7)
,
(7)
,
(8)
,
(8)
,
(9)
,
(9)
,
(9)
,
(10)
,
(10)
,
(10)
,
(10)
,
(10)
,
(11)
,
(11)
,
(11)
,
(11)
,
(12)
,
(12)
,
(12)
,
(13)
,
(13)
,
(13)
,
(13)
,
(13)
,
(14)
,
(14)
,
(14)
,
(15)
,
(15)
,
(15)
,
(15)
,
(15)
,
(16)
,
(16)
,
(17)
,
(17)
,
(18)
,
(18)
,
(18)
,
(19)
,
(19)
,
(20)
,
(20)
,
(20)
,
(20)
,
(21)
,
(21)
,
(22)
,
(22)
,
(23)
,
(23)
1
2
3
4
5
6
7
8
9
10
11
12
13
14
15
16
17
18
19
20
21
22
23
2
3
4
5
6
7
8
9
10
11
12
13
14
15
16
17
18
19
20
21
22
23
Valerie Lorin
- Function : Author
- PersonId : 184959
- IdHAL : valerie-lorin
- ORCID : 0000-0003-1760-1585
- IdRef : 253119871
Valérie Monceaux
- Function : Author
- PersonId : 804944
- ORCID : 0000-0002-8599-2146
Sylvie Orr
- Function : Author
- PersonId : 825822
- ORCID : 0000-0001-9359-4909
Jérémy Dufloo
- Function : Author
- PersonId : 791683
- ORCID : 0000-0002-4963-1378
- IdRef : 264617762
Olivier Schwartz
- Function : Author
- PersonId : 757442
- ORCID : 0000-0002-0729-1475
- IdRef : 128673850
Laurence Meyer
- Function : Author
- PersonId : 756223
- ORCID : 0000-0001-5707-2062
Laurent Hocqueloux
- Function : Author
- PersonId : 765803
- ORCID : 0000-0002-2264-4822
Asier Sáez-Cirión
- Function : Author
- PersonId : 184176
- IdHAL : asier-saez-cirion
- ORCID : 0000-0003-2406-7536
Hugo Mouquet
Connectez-vous pour contacter l'auteur
- Function : Correspondent author
- PersonId : 996459
Connectez-vous pour contacter l'auteur
Anrs Visconti Study Group
- Function : Author
Thierry Prazuck
- Function : Author
Barbara De Dieuleveult
- Function : Author
Firouzé Bani-Sadr
- Function : Author
- PersonId : 770044
- ORCID : 0000-0001-8268-866X
- IdRef : 120562642
Maxime Hentzien
- Function : Author
- PersonId : 735268
- IdHAL : maxime-hentzien
- ORCID : 0000-0003-2729-9420
- IdRef : 196441293
Abstract
HIV-1 post-treatment controllers are rare individuals controlling HIV-1 infection for years after antiretroviral therapy interruption. Identification of immune correlates of control in post-treatment controllers could aid in designing effective HIV-1 vaccine and remission strategies. Here, we perform comprehensive immunoprofiling of the humoral response to HIV-1 in long-term post-treatment controllers. Global multivariate analyses combining clinico-virological and humoral immune data reveal distinct profiles in post-treatment controllers experiencing transient viremic episodes off therapy compared to those stably aviremic. Virally-exposed post-treatment controllers display stronger HIV-1 humoral responses, and develop more frequently Env-specific memory B cells and cross-neutralizing antibodies. Both are linked to short viremic exposures, which are also accompanied by an increase in blood atypical memory B cells and activated subsets of circulating follicular helper T cells. Still, most humoral immune variables only correlate with Th2-like circulating follicular helper T cells. Thus, post-treatment controllers form a heterogeneous group with two distinct viral behaviours and associated immune signatures. Post-treatment controllers stably aviremic present “silent” humoral profiles, while those virally-exposed develop functionally robust HIV-specific B-cell and antibody responses, which may participate in controlling infection.
Origin : Publication funded by an institution