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Journal Articles Nature Communications Year : 2022

Transient viral exposure drives functionally-coordinated humoral immune responses in HIV-1 post-treatment controllers

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Valerie Lorin
Jérémy Dufloo
Olivier Schwartz
Laurent Hocqueloux
Anrs Visconti Study Group
  • Function : Author
Thierry Prazuck
  • Function : Author
Barbara De Dieuleveult
  • Function : Author
Maxime Hentzien
Gilles Hittinger
  • Function : Author
Véronique Lambry
  • Function : Author
Gilles Pialoux
  • Function : Author
Martin Siguier
  • Function : Author
Anne Adda
  • Function : Author
Jane Foucoin
  • Function : Author

Abstract

HIV-1 post-treatment controllers are rare individuals controlling HIV-1 infection for years after antiretroviral therapy interruption. Identification of immune correlates of control in post-treatment controllers could aid in designing effective HIV-1 vaccine and remission strategies. Here, we perform comprehensive immunoprofiling of the humoral response to HIV-1 in long-term post-treatment controllers. Global multivariate analyses combining clinico-virological and humoral immune data reveal distinct profiles in post-treatment controllers experiencing transient viremic episodes off therapy compared to those stably aviremic. Virally-exposed post-treatment controllers display stronger HIV-1 humoral responses, and develop more frequently Env-specific memory B cells and cross-neutralizing antibodies. Both are linked to short viremic exposures, which are also accompanied by an increase in blood atypical memory B cells and activated subsets of circulating follicular helper T cells. Still, most humoral immune variables only correlate with Th2-like circulating follicular helper T cells. Thus, post-treatment controllers form a heterogeneous group with two distinct viral behaviours and associated immune signatures. Post-treatment controllers stably aviremic present “silent” humoral profiles, while those virally-exposed develop functionally robust HIV-specific B-cell and antibody responses, which may participate in controlling infection.
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Origin : Publication funded by an institution

Dates and versions

pasteur-03654232 , version 1 (28-04-2022)

Licence

Attribution - CC BY 4.0

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Luis Molinos-Albert, Valerie Lorin, Valérie Monceaux, Sylvie Orr, Asma Essat, et al.. Transient viral exposure drives functionally-coordinated humoral immune responses in HIV-1 post-treatment controllers. Nature Communications, 2022, 13 (1), pp.1944. ⟨10.1038/s41467-022-29511-1⟩. ⟨pasteur-03654232⟩
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