Skip to Main content Skip to Navigation
Journal articles

Functional compensation precedes recovery of tissue mass following acute liver injury

Abstract : The liver plays a central role in metabolism, protein synthesis and detoxification. It possesses unique regenerative capacity upon injury. While many factors regulating cellular proliferation during liver repair have been identified, the mechanisms by which the injured liver maintains vital functions prior to tissue recovery are unknown. Here, we identify a new phase of functional compensation following acute liver injury that occurs prior to cellular proliferation. By coupling single-cell RNA-seq with in situ transcriptional analyses in two independent murine liver injury models, we discover adaptive reprogramming to ensure expression of both injury response and core liver function genes dependent on macrophage-derived WNT/βcatenin signaling. Interestingly, transcriptional compensation is most prominent in nonproliferating cells, clearly delineating two temporally distinct phases of liver recovery. Overall, our work describes a mechanism by which the liver maintains essential physiological functions prior to cellular reconstitution and characterizes macrophage-derived WNT signals required for this compensation.
Document type :
Journal articles
Complete list of metadata

https://hal-pasteur.archives-ouvertes.fr/pasteur-03648876
Contributor : Marie Lemesle Connect in order to contact the contributor
Submitted on : Friday, April 22, 2022 - 9:30:29 AM
Last modification on : Saturday, April 23, 2022 - 3:33:20 AM

File

s41467-020-19558-3.pdf
Publication funded by an institution

Licence


Distributed under a Creative Commons Attribution 4.0 International License

Identifiers

Collections

Citation

Chad Walesky, Kellie Kolb, Carolyn Winston, Jake Henderson, Benjamin Kruft, et al.. Functional compensation precedes recovery of tissue mass following acute liver injury. Nature Communications, Nature Publishing Group, 2020, 11 (1), pp.5785. ⟨10.1038/s41467-020-19558-3⟩. ⟨pasteur-03648876⟩

Share

Metrics

Record views

13

Files downloads

10