HAL will be down for maintenance from Friday, June 10 at 4pm through Monday, June 13 at 9am. More information
Skip to Main content Skip to Navigation
Journal articles

Spindle-shaped archaeal viruses evolved from rod-shaped ancestors to package a larger genome

Abstract : Spindle- or lemon-shaped viruses infect archaea in diverse environments. Due to the highly pleomorphic nature of these virions, which can be found with cylindrical tails emanating from the spindle-shaped body, structural studies of these capsids have been challenging. We have determined the atomic structure of the capsid of Sulfolobus monocaudavirus 1, a virus that infects hosts living in nearly boiling acid. A highly hydrophobic protein, likely integrated into the host membrane before the virions assemble, forms 7 strands that slide past each other in both the tails and the spindle body. We observe the discrete steps that occur as the tail tubes expand, and these are due to highly conserved quasiequivalent interactions with neighboring subunits maintained despite significant diameter changes. Our results show how helical assemblies can vary their diameters, becoming nearly spherical to package a larger genome and suggest how all spindle-shaped viruses have evolved from archaeal rod-like viruses.
Document type :
Journal articles
Complete list of metadata

https://hal-pasteur.archives-ouvertes.fr/pasteur-03620791
Contributor : Mart Krupovic Connect in order to contact the contributor
Submitted on : Saturday, March 26, 2022 - 5:53:23 PM
Last modification on : Friday, April 15, 2022 - 10:45:29 AM

File

 Restricted access
To satisfy the distribution rights of the publisher, the document is embargoed until : 2022-09-23

Please log in to resquest access to the document

Identifiers

Collections

Citation

Fengbin Wang, Virginija Cvirkaite-Krupovic, Matthijn Vos, Leticia Beltran, Mark A.B. Kreutzberger, et al.. Spindle-shaped archaeal viruses evolved from rod-shaped ancestors to package a larger genome. Cell, Elsevier, 2022, 185 (8), pp.1297-1307.e11. ⟨10.1016/j.cell.2022.02.019⟩. ⟨pasteur-03620791⟩

Share

Metrics

Record views

28