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Journal articles
Signature-Tagged Transposon Mutagenesis Identifies Novel Mycobacterium tuberculosis Genes Involved in the Parasitism of Human Macrophages
Vania Rosas-Magallanes
1
Gustavo Stadthagen-Gomez
1
Jean Rauzier
1
Luis Barreiro
1
Ludovic Tailleux
1
Frédéric Boudou
1
Ruth Griffin
2
Jérome Nigou
3
Mary Jackson
1
Brigitte Gicquel
1
Olivier Neyrolles
1, *
Vania Rosas-Magallanes 1
Author
Gustavo Stadthagen-Gomez 1
Author
Jean Rauzier 1
Author
Luis Barreiro 1
Author
1
Génétique mycobactérienne - Mycobacterial genetics (Département Génomes et Génétique, 25-28, rue du Docteur Roux 75724 PARIS Cedex 15 - France)
- Institut Pasteur [Paris] (25-28, rue du docteur Roux, 75724 Paris cedex 15 - France)
2
Imperial College London (South Kensington Campus, London SW7 2AZ - United Kingdom)
3
IPBS - Institut de pharmacologie et de biologie structurale (205 Route de Narbonne 31077 TOULOUSE CEDEX 4 - France)
- CNRS - Centre National de la Recherche Scientifique : UMR5089 (France)
- UT3 - Université Toulouse III - Paul Sabatier (118 route de Narbonne - 31062 Toulouse - France)
- Université Fédérale Toulouse Midi-Pyrénées (41 Allée Jules Guesde, 31000 Toulouse - France)
Abstract : Using signature-tagged transposon mutagenesis, we isolated 23 Mycobacterium tuberculosis mutants, corresponding to 21 genes or genetic regions, attenuated in their ability to parasitize human macrophages. Mutants disrupted in the ABC transporter-encoding genes Rv0986 and Rv0987 were further characterized as being impaired in their ability to bind to host cells.
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Journal articles
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https://hal-pasteur.archives-ouvertes.fr/pasteur-03525490
Contributor : Ludovic Tailleux Connect in order to contact the contributor
Submitted on : Thursday, January 13, 2022 - 9:51:38 PM
Last modification on : Thursday, April 7, 2022 - 10:10:29 AM
Contributor : Ludovic Tailleux Connect in order to contact the contributor
Submitted on : Thursday, January 13, 2022 - 9:51:38 PM
Last modification on : Thursday, April 7, 2022 - 10:10:29 AM
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- HAL Id : pasteur-03525490, version 1
- DOI : 10.1128/IAI.00058-06
- PUBMED : 17030567
- PUBMEDCENTRAL : PMC1828433
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PASTEUR | UNIV-TLSE3 | IPBS | CNRS
Citation
Vania Rosas-Magallanes, Gustavo Stadthagen-Gomez, Jean Rauzier, Luis Barreiro, Ludovic Tailleux, et al.. Signature-Tagged Transposon Mutagenesis Identifies Novel Mycobacterium tuberculosis Genes Involved in the Parasitism of Human Macrophages. Infection and Immunity, American Society for Microbiology, 2007, 75 (1), pp.504-507. ⟨10.1128/IAI.00058-06⟩. ⟨pasteur-03525490⟩
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