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Signature-Tagged Transposon Mutagenesis Identifies Novel Mycobacterium tuberculosis Genes Involved in the Parasitism of Human Macrophages

Vania Rosas-Magallanes 1 Gustavo Stadthagen-Gomez 1 Jean Rauzier 1 Luis Barreiro 1 Ludovic Tailleux 1 Frédéric Boudou 1 Ruth Griffin 2 Jérome Nigou 3 Mary Jackson 1 Brigitte Gicquel 1 Olivier Neyrolles 1, * 
* Corresponding author
1 Génétique mycobactérienne - Mycobacterial genetics
2 Imperial College London
3 IPBS - Institut de pharmacologie et de biologie structurale
Abstract : Using signature-tagged transposon mutagenesis, we isolated 23 Mycobacterium tuberculosis mutants, corresponding to 21 genes or genetic regions, attenuated in their ability to parasitize human macrophages. Mutants disrupted in the ABC transporter-encoding genes Rv0986 and Rv0987 were further characterized as being impaired in their ability to bind to host cells.
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https://hal-pasteur.archives-ouvertes.fr/pasteur-03525490
Contributor : Ludovic Tailleux Connect in order to contact the contributor
Submitted on : Thursday, January 13, 2022 - 9:51:38 PM
Last modification on : Monday, July 4, 2022 - 9:49:26 AM

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Vania Rosas-Magallanes, Gustavo Stadthagen-Gomez, Jean Rauzier, Luis Barreiro, Ludovic Tailleux, et al.. Signature-Tagged Transposon Mutagenesis Identifies Novel Mycobacterium tuberculosis Genes Involved in the Parasitism of Human Macrophages. Infection and Immunity, American Society for Microbiology, 2007, 75 (1), pp.504-507. ⟨10.1128/IAI.00058-06⟩. ⟨pasteur-03525490⟩

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