Signature-Tagged Transposon Mutagenesis Identifies Novel Mycobacterium tuberculosis Genes Involved in the Parasitism of Human Macrophages - Archive ouverte HAL Access content directly
Journal Articles Infection and Immunity Year : 2007

Signature-Tagged Transposon Mutagenesis Identifies Novel Mycobacterium tuberculosis Genes Involved in the Parasitism of Human Macrophages

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Abstract

Using signature-tagged transposon mutagenesis, we isolated 23 Mycobacterium tuberculosis mutants, corresponding to 21 genes or genetic regions, attenuated in their ability to parasitize human macrophages. Mutants disrupted in the ABC transporter-encoding genes Rv0986 and Rv0987 were further characterized as being impaired in their ability to bind to host cells.

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pasteur-03525490 , version 1 (13-01-2022)

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Vania Rosas-Magallanes, Gustavo Stadthagen-Gomez, Jean Rauzier, Luis Barreiro, Ludovic Tailleux, et al.. Signature-Tagged Transposon Mutagenesis Identifies Novel Mycobacterium tuberculosis Genes Involved in the Parasitism of Human Macrophages. Infection and Immunity, 2007, 75 (1), pp.504-507. ⟨10.1128/IAI.00058-06⟩. ⟨pasteur-03525490⟩
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