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Journal articles
A murine DC-SIGN homologue contributes to early host defense against Mycobacterium tuberculosis
Antoine Tanne
1, 2
Bo Ma
3
Ludovic Tailleux
1
Frédéric Boudou
1
Hélène Botella
2
Edgar Badell
1
Florence Levillain
2
Maureen Taylor
4
Kurt Drickamer
4
Jérome Nigou
2
Karen Dobos
5
Germain Puzo
2
Dietmar Vestweber
6
Martin Wild
6
Marie Marcinko
3
Peter Sobieszczuk
3
Lauren Stewart
3
Daniel Lebus
3
Brigitte Gicquel
1
Olivier Neyrolles
2, 1, *
*
Corresponding author
Lauren Stewart 3
Author
Daniel Lebus 3
Author
Brigitte Gicquel 1
Author
Olivier Neyrolles 2, 1
Correspondent author IdHAL : olivier-neyrolles ORCID : https://orcid.org/0000-0003-0047-5885
1
Génétique mycobactérienne - Mycobacterial genetics (Département Génomes et Génétique, 25-28, rue du Docteur Roux 75724 PARIS Cedex 15 - France)
- Institut Pasteur [Paris] (25-28, rue du docteur Roux, 75724 Paris cedex 15 - France)
2
IPBS - Institut de pharmacologie et de biologie structurale (205 Route de Narbonne 31077 TOULOUSE CEDEX 4 - France)
- CNRS - Centre National de la Recherche Scientifique : UMR5089 (France)
- UT3 - Université Toulouse III - Paul Sabatier (118 route de Narbonne - 31062 Toulouse - France)
- Université Fédérale Toulouse Midi-Pyrénées (41 Allée Jules Guesde, 31000 Toulouse - France)
3
The Scripps Research Institute [La Jolla] (10550 N. Torrey Pines rd, La Jolla, CA 92037 - United States)
- UC San Diego - University of California [San Diego] (9500 Gilman Dr., La Jolla, CA 92093 USA - United States)
- University of California (United States)
4
Imperial College London (South Kensington Campus, London SW7 2AZ - United Kingdom)
5
CSU - Colorado State University [Fort Collins] (Colorado State University, Fort Collins, Colorado 80523 USA - United States)
6
Max Planck Institute for Molecular Biomedicine (Röntgenstraße 20, 48149 Münster - Germany)
- Max-Planck-Gesellschaft (Jägerstrasse, 10-11, D-10117 Berlin - Germany)
Abstract : The C-type lectin dendritic cell−specific intercellular adhesion molecule-3 grabbing nonintegrin (DC-SIGN) mediates the innate immune recognition of microbial carbohydrates. We investigated the function of this molecule in the host response to pathogens in vivo, by generating mouse lines lacking the DC-SIGN homologues SIGNR1, SIGNR3, and SIGNR5. Resistance to Mycobacterium tuberculosis was impaired only in SIGNR3-deficient animals. SIGNR3 was expressed in lung phagocytes during infection, and interacted with M. tuberculosis bacilli and mycobacterial surface glycoconjugates to induce secretion of critical host defense inflammatory cytokines, including tumor necrosis factor (TNF). SIGNR3 signaling was dependent on an intracellular tyrosine-based motif and the tyrosine kinase Syk. Thus, the mouse DC-SIGN homologue SIGNR3 makes a unique contribution to protection of the host against a pulmonary bacterial pathogen.
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Journal articles
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https://hal-pasteur.archives-ouvertes.fr/pasteur-03525480
Contributor : Ludovic Tailleux Connect in order to contact the contributor
Submitted on : Thursday, January 13, 2022 - 9:28:46 PM
Last modification on : Thursday, April 7, 2022 - 10:10:29 AM
Long-term archiving on: : Thursday, April 14, 2022 - 11:44:39 PM
Contributor : Ludovic Tailleux Connect in order to contact the contributor
Submitted on : Thursday, January 13, 2022 - 9:28:46 PM
Last modification on : Thursday, April 7, 2022 - 10:10:29 AM
Long-term archiving on: : Thursday, April 14, 2022 - 11:44:39 PM
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jem_20090188.pdf
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Distributed under a Creative Commons Attribution - ShareAlike 4.0 International License
Identifiers
- HAL Id : pasteur-03525480, version 1
- DOI : 10.1084/jem.20090188
- PUBMED : 19770268
- PUBMEDCENTRAL : PMC2757888
Collections
PASTEUR | UNIV-TLSE3 | IPBS | CNRS
Citation
Antoine Tanne, Bo Ma, Ludovic Tailleux, Frédéric Boudou, Hélène Botella, et al.. A murine DC-SIGN homologue contributes to early host defense against Mycobacterium tuberculosis. Journal of Experimental Medicine, Rockefeller University Press, 2009, 206 (10), pp.2205-2220. ⟨10.1084/jem.20090188⟩. ⟨pasteur-03525480⟩
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