Probing Host Pathogen Cross-Talk by Transcriptional Profiling of Both Mycobacterium tuberculosis and Infected Human Dendritic Cells and Macrophages

Ludovic Tailleux (1) , Simon Waddell (2) , Mattia Pelizzola (3) , Alessandra Mortellaro (3) , Michael Withers (4) , Antoine Tanne (1) , Paola Ricciardi Castagnoli (3) , Brigitte Gicquel (1) , Neil Stoker (4) , Philip Butcher (2) , Maria Foti (3) , Olivier Neyrolles (1)

1 Génétique mycobactérienne - Mycobacterial genetics
2 St George's, University of London
3 UNIMIB - Università degli Studi di Milano-Bicocca = University of Milano-Bicocca
4 Royal Veterinary College [London]

Transcriptional profiling using microarrays provides a unique opportunity to decipher host pathogen cross-talk on the global level. Here, for the first time, we have been able to investigate gene expression changes in both Mycobacterium tuberculosis, a major human pathogen, and its human host cells, macrophages and dendritic cells.

Domaines: Sciences du Vivant [q-bio]; Immunologie; Bactériologie

Ludovic Tailleux, Simon Waddell, Mattia Pelizzola, Alessandra Mortellaro, Michael Withers, et al.. Probing Host Pathogen Cross-Talk by Transcriptional Profiling of Both Mycobacterium tuberculosis and Infected Human Dendritic Cells and Macrophages. PLoS ONE, 2008, 3 (1), pp.e1403. ⟨10.1371/journal.pone.0001403⟩. ⟨pasteur-03525478⟩