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Probing Host Pathogen Cross-Talk by Transcriptional Profiling of Both Mycobacterium tuberculosis and Infected Human Dendritic Cells and Macrophages

Ludovic Tailleux 1 Simon Waddell 2 Mattia Pelizzola 3 Alessandra Mortellaro 3 Michael Withers 4 Antoine Tanne 1 Paola Ricciardi Castagnoli 3 Brigitte Gicquel 1 Neil Stoker 4 Philip Butcher 2 Maria Foti 3 Olivier Neyrolles 1
1 Génétique mycobactérienne - Mycobacterial genetics
2 St George's, University of London
3 UNIMIB - Università degli Studi di Milano-Bicocca [Milano]
4 Royal Veterinary College [London]
Abstract : Transcriptional profiling using microarrays provides a unique opportunity to decipher host pathogen cross-talk on the global level. Here, for the first time, we have been able to investigate gene expression changes in both Mycobacterium tuberculosis, a major human pathogen, and its human host cells, macrophages and dendritic cells.
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Submitted on : Thursday, January 13, 2022 - 9:20:59 PM
Last modification on : Friday, January 14, 2022 - 5:13:44 PM

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Ludovic Tailleux, Simon Waddell, Mattia Pelizzola, Alessandra Mortellaro, Michael Withers, et al.. Probing Host Pathogen Cross-Talk by Transcriptional Profiling of Both Mycobacterium tuberculosis and Infected Human Dendritic Cells and Macrophages. PLoS ONE, Public Library of Science, 2008, 3 (1), pp.e1403. ⟨10.1371/journal.pone.0001403⟩. ⟨pasteur-03525478⟩

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